Human immunodeficiency Virus (HIV)

CAS No.	Product Name	Inquiry
136777-48-5	2-Cyclopentene-1-methanol,4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-,hydrochloride (1:1), (1S,4R)- Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. It can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses telomerase activity.
136816-75-6	Atevirdine
136817-59-9	Delavirdine Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1.
13728-56-8	HIV-1 Nef-IN-1 HIV-1 Nef-IN-1, an inhibitor of HIV-1 Nef protein, can effectively compete for Nef-SH3Hck interactions with a Kd of 6.7 μM.
1374035-59-2	DMJ-I-228
137448-39-6	HIV-1-inhibitor-47 HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect.
137487-62-8	Alvircept sudotox
138483-63-3	L-689502 A potent inhibitor of HIV-l protease (IC50= 1 nM)
1391052-30-4	Lamivudine-13C-15N2 Lamivudine 13C,15N2 is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus.
1392312-45-6	BMS-955176 BMS-955176 is the second generation HIV-1 maturation inhibitor.
139339-45-0	TOPOTECAN(TPT) Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects.
139694-65-8	KNI-102
139934-80-8	L 694746
1401924-49-9	NVP018
140207-93-8	Pentosan Polysulfate Sodium Pentosan polysulfate sodium is a biomedical product used for treating interstitial cystitis, a chronic bladder condition causing pain and frequent urination. This compound acts as an anticoagulant and a urinary protectant, reducing inflammation and restoring the integrity of the bladder lining.
14110-64-6	Cytochalasin A It is produced by the strain of Helminthosporium dematioideum, Coriolus vernicipes. It has many biological activities, such as inhibiting cytokinesis reversibly, inhibiting megasophil endocytosis and exocytosis. Cytochalasin A is an HIV protease inhibitor.
141117-12-6	Celgosivir hydrochloride Celgosivir hydrochloride is the hydrochloride salt of Celgosivir which is anα-glucosidase inhibitor and inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in vitro assay.
141237-50-5	HIV-1 Rev 34-50 HIV-1 Rev (34-50) is a 17-aa cell-penetrating peptide derived from HIV-1 Rev protein residue 34-50. It is an RNA-binding peptide that has been used to deliver macromolecules into cells.
141497-12-3	H-Gly-Pro-Gly-NH2 H-Gly-Pro-Gly-NH2 inhibits HIV-1 replication through its metabolite α-hydroxyglycineamide. It increases the antiviral activity of zidovudine and ritonavir.
1415559-43-1	CDK9-IN-1 Among CDKs, CDK9 is a validated pathological target in HIV infection, inflammation and cardiac hypertrophy; however selective CDK9 inhibitors are still not available. We present a selective inhibitor family of CDK9 based on the 4-phenylamino-6- phenylpyrimidine nucleus. We show a convenient synthetic method to prepare a useful intermediate and its derivatisation resulting in novel compounds. The CDK9 inhibitory activity of the derivatives was measured in specific kinase assay and the CDK inhibitory profile of the best ones (IC50 > 100nM) was determined. The most selective compounds had high selectivity over CDK1, 2, 3, 5, 6, 7 and showed at least one order of magnitude higher inhibitory activity over CDK4 inhibition. The most selective molecules were examined in cytotoxicity assays and their ability to inhibit HIV-1 replication was determined in cellular assays.

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