Human immunodeficiency Virus (HIV)

all Activators (8) Antagonists (4) Inducer (1) Inhibitors (721)

CAS No.	Product Name	Inquiry
1189994-89-5	5-Hydroxy Valproic acid-[d7] sodium salt 5-Hydroxy Valproic acid-[d7] sodium salt is the labelled analogue of 5-Hydroxy Valproic acid sodium salt, which is a metabolite of Valproic Acid.
119139-55-8	Interiorin Interiorin is a lignan isolated from Kadsura heteroclita. Interiorin exhibits anti-HIV activity.
1192224-24-0	Dealkyl Atazanavir An impurity of Atazanavir
1206161-97-8	Filgotinib Filgotinib is a potent and selective JAK1 inhibitor exhibiting 30-fold selectivity over JAK2. It was shown to inhibit Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro. Filgotinib has the potential for the treatment of rheumatoid arthritis and possibly other immune-inflammatory diseases.
121104-96-9	6-O-butyl castanospermine Celgosivir, an effective α-glucosidase I inhibitor, has been found to be related to viral maturation and is still under Phase I/II trial against Dengue. IC50: 16 and 47 umol/L (through plaque assay and a cytopathic assay).
1217629-70-3	Nelfinavir-[d3] Nelfinavir-[d3] is the labelled analogue of Nelfinavir, which is a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor.
1217661-20-5	Amprenavir-[d4] Amprenavir-[d4] is a labelled analogue of Amprenavir. Amprenavir promotes the specific interactions between the nuclear receptor pregnane X receptor (PXR) and the coactivators SRC-1 and PBP.
1217819-15-2	Tipranavir-[d4] Tipranavir-[d4] is the labelled analogue of Tipranavir, which is a nonpeptidic HIV protease inhibitor and has been found to be effective as an antiviral.
12192-57-3	Aurothioglucose Aurothioglucose is used in the treatment of rheumatoid arthritis and psoriasis.
1219803-67-4	Stavudine-[d4] An isotope labelled Stavudine. Stavudine is an antiretroviral medication used to prevent and treat HIV/AIDS.
1224729-35-4	Lopinavir-[d8] Lopinavir-[d8] is the labelled form of Lopinavir, which is a selective HIV protease inhibitor used as an antiretroviral medication.
123135-05-7	Uncaric acid Uncaric acid is isolated from the vines of Uncaria thwaitesii, has antituberculosis action. It would make ideal drugs for the treatment of many neuroinflammatory and neurodegenerative disorders.
1236287-04-9	Tenofovir maleate Tenofovir hydrate reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir hydrate also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir hydrate inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir hydrate (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir hydrate inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 ?M for wild-type RT, 6 ?M for M184V RT and 50 ?M for K65R RT. Tenofovir hydrate (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir hydrate treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir hydrate (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques.
123629-42-5	gp120-IN-2 gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC50 of 7.5 µM and CC50 of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells.
1246812-58-7	rac Efavirenz-[d4] Rac Efavirenz-[d4] is an isotope compound of rac Efavirenz. Efavirenz is an NNRTI that prevents RNA plus-strand initiation with an IC50 value of 17 nM. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It has been used in combination therapy with drugs directed at the treatment of opportunistic infections such as HIV and cancer.
1246816-98-7	Raltegravir-[d3] Potassium Salt Labelled Raltegravir K salt. Raltegravir is a potent, selective, and orally bioavailable inhibitor of HIV integrase (IC50 = 15 nM). It is metabolized primarily by uridine diphosphate glucuronosyltransferase 1A. Raltegravir has long-term efficacy and safety in managing HIV-1 infection in adults, children, and adolescents.
1246819-87-3	Plerixafor-[d4] Plerixafor-[d4] is the labelled analogue of Plerixafor, which is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5. 7 nM, respectively.
1258453-75-6	Obefazimod Obefazimod is an immunomodulator.
1259330-61-4	Sparstolonin-B Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.
1260619-56-4	Abacavir-[d4] Abacavir-[d4] is the labelled analogue of Abacavir, which is a nucleoside reverse transcriptase inhibitor.

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