Human immunodeficiency Virus (HIV)

CAS No.	Product Name	Inquiry
12192-57-3	Aurothioglucose Aurothioglucose is used in the treatment of rheumatoid arthritis and psoriasis.
1219803-67-4	Stavudine-[d4] An isotope labelled Stavudine. Stavudine is an antiretroviral medication used to prevent and treat HIV/AIDS.
1224729-35-4	Lopinavir-d8 Lopinavir-d8 (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM.
123135-05-7	Uncaric acid Uncaric acid is isolated from the vines of Uncaria thwaitesii, has antituberculosis action. It would make ideal drugs for the treatment of many neuroinflammatory and neurodegenerative disorders.
1236287-04-9	Tenofovir maleate Tenofovir hydrate reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir hydrate also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir hydrate inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir hydrate (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir hydrate inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 ?M for wild-type RT, 6 ?M for M184V RT and 50 ?M for K65R RT. Tenofovir hydrate (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir hydrate treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir hydrate (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques.
123629-42-5	gp120-IN-2 gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC50 of 7.5 µM and CC50 of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells.
1246812-58-7	rac Efavirenz-[d4] Rac Efavirenz-[d4] is an isotope compound of rac Efavirenz. Efavirenz is an NNRTI that prevents RNA plus-strand initiation with an IC50 value of 17 nM. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It has been used in combination therapy with drugs directed at the treatment of opportunistic infections such as HIV and cancer.
1246816-98-7	Raltegravir-[d3] Potassium Salt Labelled Raltegravir K salt. Raltegravir is a potent, selective, and orally bioavailable inhibitor of HIV integrase (IC50 = 15 nM). It is metabolized primarily by uridine diphosphate glucuronosyltransferase 1A. Raltegravir has long-term efficacy and safety in managing HIV-1 infection in adults, children, and adolescents.
1246819-87-3	Plerixafor-[d4] Plerixafor-[d4] is the labelled analogue of Plerixafor, which is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5. 7 nM, respectively.
1258453-75-6	Obefazimod Obefazimod is an immunomodulator.
1259330-61-4	Sparstolonin-B Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.
1260619-56-4	Abacavir-[d4] Abacavir-[d4] is the labelled analogue of Abacavir, which is a nucleoside reverse transcriptase inhibitor.
1260629-43-3	B07 B07 hydrochloride is a CCR5 antagonist.
1261394-62-0	Efavirenz-[13C6] Efavirenz-[13C6], is the labelled analogue of Efavirenz. Efavirenz is an antiretroviral medication used to treat and prevent HIV/AIDS.
1264-62-6	ERYTHROMYCIN ETHYLSUCCINATE Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.
12650-88-3	Lysozyme from chicken egg white It's a bactericidal enzyme found in eggs that lyses gram-positive bacteria.
127-07-1	N-Hydroxyurea Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
127779-20-8	Saquinavir An HIV protease inhibitor. It is often used in combination with ritonavir or lopinavir/ritonavir for HIV/AIDS infection therapy.
1282040-14-5	3'-Azido-3'-deoxy-5-methylcytidine 3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells.
1292804-07-9	Raltegravir-sodium Raltegravir (MK 0518) sodium is a potent and orally active integrase (IN) inhibitor, used to treat HIV infection.

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