Filovirus

As one of the most lethal of primate pathogens, filoviruses are capable of causing lethal hemorrhagic fevers. Filoviruses include various strains such as Ebolavirus (EBOVs), including Sudan ebolavirus (SEBOV), Zairean ebolavirus (ZEBOV), Ivory Coast ebolavirus (CIEBOV) and Reston ebolavirus (REBOV). Through a series of experiments, researchers have identified small drug molecules that can inhibit filoviruses such as Ebola and Marburg.

Filovirus infections usually affect multiple organs in the body and are often accompanied by bleeding (hemorrhage). Once the virus is transmitted from an animal host to a human, it can be transmitted through human-to-human contact. There is evidence that the folding of the glycoproteins of many filoviruses is more dependent upon the calnexin pathway of protein folding than most host glycoproteins. Therefore, small-molecule drugs that inhibit this pathway are expected to be selectively antiviral.

CAS No.	Product Name	Inquiry
	EBOV-GP-IN-1 EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC50 of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP).
1201652-50-7	Retro-2 Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 µM in HeLa cells. Retro-2 induces cell Autophagy.
222631-44-9	BCX 4430 hydrochloride BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells. Interfering with the replication process is a well-established antiviral strategy that has been successfully exploited in developing such life-saving drugs as the nucleoside inhibitors of HIV and acyclovir for herpes simplex complex. BCX4430 may be suitable for administration by intravenous (IV), intramuscular (IM), and oral (PO) routes.
2479465-67-1	EBOV/MARV-IN-1 EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV) with EC50s of 0.31 and 0.82 µM, respectively. It has broad-spectrum activity and low cytotoxicity (SI>100) in HeLa cells.
249503-25-1	BCX4430 freebase BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells. Interfering with the replication process is a well-established antiviral strategy that has been successfully exploited in developing such life-saving drugs as the nucleoside inhibitors of HIV and acyclovir for herpes simplex complex. BCX4430 may be suitable for administration by intravenous (IV), intramuscular (IM), and oral (PO) routes.
675104-49-1	DSHS00884 DSHS00884 is a potent human papillomavirus E6 inhibitor with an IC50 of 10 μM.

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Filovirus

EBOV-GP-IN-1

Retro-2

BCX 4430 hydrochloride

EBOV/MARV-IN-1

BCX4430 freebase

DSHS00884