Cytomegalovirus (CMV)

Cytomegalovirus is a double-stranded DNA virus and is a member of the ubiquitous family. Cytomegalovirus can escape immunological clearance and persist throughout life in the infected host. Cytomegalovirus have posed a serious threat to the health of hematopoietic stem cell transplant (HSCT) patients. BOC Sciences offers a range of antiviral drugs including valganciclovir, ganciclovir, cidofovir, phosphonovir, or combination formulations to address cytomegalovirus infection issues.

Cytomegalovirus (CMV) infection may be asymptomatic in healthy individuals, but can be life-threatening in immunocompromised patients. BOC Sciences offers innovative drugs for the prevention and control of cytomegalovirus, providing a wider range of clinical options for prophylaxis and new strategies for cytomegalovirus prevention and control for blood transplant surgeons.

CAS No.	Product Name	Inquiry
1177798-88-7	BRACO 19 trihydrochloride BRACO 19 trihydrochloride is a telomerase inhibitor (IC50 = 115 nM) that suppresses the expression of human telomerase reverse transcriptase (hTERT) and induces cellular senescence. BRACO 19 was shown to inhibit growth of uterine cancer cells in vitro and growth of uterine tumor xenografts in mice.
119139-23-0	3,4-Di(3-indolyl)-1H-pyrrole-2,5-dione Bisindolylmaleimide IV (BIM IV) is an inhibitor of pyruvate phosphate dikinase (PPDK). It is a cell-permeable potent and somewhat selective inhibitor of PKC with IC50 of 87 nM. BIM IV is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 µM. It also inhibits protein kinase A (PKA) with an IC50 of 2.7 μM.
127757-45-3	Cyclic-HPMPC Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model.
1359968-33-4	Ganciclovir-hydrate Ganciclovir (BW 759) hydrate, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovirhydrate also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir hydrate inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir hydrate has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.
160369-77-7	Fomivirsen sodium Fomivirsen sodium, an antisense 21 mer phosphorothioate oligonucleotide, is an antiviral drug used in cytomegalovirus retinitis (CMV) studies, including AIDS. It binds to and degrades mRNAs encoding the CMV immediate early 2 protein (required for viral replication), thereby providing biological activity for CMV retinitis by inhibiting viral proliferation.
175865-60-8	Valganciclovir In cell culture model systems using Caco-2 cells for PEPT1 and SKPT cells for PEPT2, valganciclovir inhibited glycylsarcosine transport mediated by PEPT1 and PEPT2 with K(i) values (inhibition constant) of 1.68+/-0.30 and 0.043+/- 0.005 mM, respectively. The inhibition by valganciclovir was competitive in both cases. 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease. Patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily orvalganciclovir 450 mg orally twice daily. None of the 20 patients randomized to valganciclovir experienced CMV reactivation (P = .004).
176161-24-3	Maribavir 1263W94 inhibited viral replication in a dose-dependent manner, with a mean 50% inhibitory concentration (IC50) of 0.12 ± 0.01 μM compared to a mean IC50 for GCV of 0.53 ± 0.04 μM, as measured by a multicycle DNA hybridization assay. Maribavir inhibits viral genome copy numbers and infectivity to levels similar to and exceeding levels produced by BGLF4 knockout virus. Introduction of 1.0 or 10 nM maribavir, a known pUL97 inhibitor, and subsequent Lineweaver-Burk analysis demonstrated competitive inhibition of CPV phosphorylation, with a Ki of 3.0+/-0.3 nM. Maribavir has significant activity against both human cytomegalovirus (CMV) and Epstein-Barr virus, but not other herpesviruses. Unlike ganciclovir, which needs to be phosphorylated by UL 97 kinase to become an active inhibitor of DNA polymerase, maribavir directly inhibits UL 97 kinase.
207226-35-5	Calcium trinatrium diethylenetriaminepentaacetic acid hydrate Calcium trinatrium diethylenetriaminepentaacetic acid hydrate is a metal chelator and useful antidote (such as acute cadmium intoxication), as well as a non-toxic CMV replication inhibitor.
233254-24-5	Tomeglovir Tomeglovir is a potent and selective inhibitor of cytomegalovirus (CMV) replication.
255730-18-8	Artemifone Artemifone is a potent and semi-synthetic antimalarial agent that can inhibit p. falciparum with an average IC50 value of 0.83 nM. It is also a potent human CMV inhibitor.
351351-75-2	Braco-19 Braco-19 is a potent telomerase/telomere inhibitor that prevents telomerase catalysis. Braco-19, as a G-quadruplex (GQ) binding ligand, stabilizes GQ formation at 3V telomeric DNA overhang and produces rapid senescence or selective cell death. It is also an HAdV virus replication inhibitor.
352554-02-0	SIRT1-IN-1 SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity. SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. It inhibits SIRT2 with an IC50 of 11.5 μM.
391680-92-5	5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl ester pUL89 Endonuclease-IN-1 (Compound 13d) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 value of 0.88 μM and has antiviral activitiy.
50-91-9	Floxuridine Floxuridine is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.
519021-48-8	pUL89-Endonuclease-IN-2 pUL89 Endonuclease-IN-2 (Compound 15k) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 of 3.0 μM.
520-32-1	Tricin Tricin, a natural flavonoid isolated from the herb of Avena sativa, exhibits potential activity of anti-inflammatory, and has diverse biological activities including antigrowth activity in several human cancer cell lines and cancer chemopreventive effects in the gastrointestinal tract of mice, might be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis. Tricin exerts potential role as a chemopreventive and anticancer agent, which indicates the compound is a potential multifunctional nutraceutical.
55726-47-1	Enocitabine Enocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus. Enocitabine has antileukemic and antiviral activities.
632325-71-4	Filociclovir Filociclovir is a broad-spectrum anti-herpesvirus compound with good antiviral activity against cytomegalovirus (CMV), herpes simplex virus (HHV)-6 and HHV-8, with EC50 values ranging from 0.7 μM to 8 μM.
69304-47-8	Brivudine Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro.
82410-32-0	Ganciclovir Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM.

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