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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
Hepatitis B Virus (HBV)
Antiviral therapy drugs for people with acute and chronic HBV infection generally focus on inhibiting viral entry as well as inhibiting the DNA polymerase of the HBV virus. There are two types of anti-hepatitis B virus drugs currently on the market, namely interferon α (regular and pegylated interferon) and 5 nucleoside (acid) analogues, the latter including lamivudine (LAM), telbivudine (LDT), entecavir (ETV), adefovir (ADV), and tenofovir (TDF).
Hepatitis B virus (HBV) infection has become a major health problem worldwide, and it can lead to chronic hepatitis, cirrhosis, and liver cancer. HBV can be divided into differences genotypes, and differences between genotypes can effect the disease severity, disease course and likelihood of complications, as well as response to treatment and possibly vaccination.
CAS No. | Product Name | Inquiry |
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452967-14-5 |
IR415IR415 is an effective anti-HBV drug that inhibits HBV replication by blocking hepatitis B virus X protein (HBx) activity. IR415 selectively interacts with HBx (Kd = 2 nM), blocks HBV-mediated RNAi inhibition and reverses the inhibitory effect of HBx protein on dicer endoribonuclease activity. |
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475650-36-3 |
InarigivirInarigivir is a dinucleotide prodrug with antiviral and immunomodulatory activity, which has the potential for the treatment of HBV infections. |
|
476617-51-3 |
Bay 41-4109 less active enantiomerBay 41-4109 less active enantiomer exhibits less activity than Bay 41-4109 that is a novel class of drugs and inhibits hepatitis B virus (HBV) capsid formation and replication. |
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526-18-1 |
OsalmidOsalmid is a ribonucleotide reductase small subunit M2 (RRM2) targeting compound that suppresses RRM2 activity in a concentration-dependent manner. |
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57378-72-0 |
Isochlorogenic acid CIsochlorogenic acid C is extracted from the flower bud of Lonicera japonica Thunb. Isochlorogenic acid C is a selective inhibitor of human immunodeficiency virus type 1 integrase. It has antioxidant activity. |
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64938-51-8 |
Schisantherin CSchisantherin C is found in Kadsura longipedunculata, which has effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. |
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776-86-3 |
IsoscopoletinIsoscopoletin is a natural coumarin found in the herbs of Paederia scandens (Lour.) Merr. |
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840529-13-7 |
Helioxanthin 8-1Helioxanthin 8-1 is an analogue of helioxanthin, which exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity. It showed the most potent antiHBV activity among those helioxanthin analogues tested. It exhibited moderately potent activity against HIV and effective inhibition on DHBV replication. It would therefore be promising to study helioxanthin analogues that contain a six-membered ring instead of the five-membered ring found in the lactam. |
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84638-48-2 |
(3R)-5,7-Dihydroxy-3-(4-hydroxybenzyl)-6-methyl-2,3-dihydro-4H-1-benzopyran-4-one(3R)-5,7-Dihydroxy-3-(4-hydroxybenzyl)-6-methyl-2,3-dihydro-4H-1-benzopyran-4-one is found in Dracaena cochinchinensis. |
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887686-02-4 |
OSS-128167OSS-128167 is a selective SIRT6 inhibitor (IC50 = 89 µM). |
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911208-73-6 |
Tenofovir exalidexTenofovir exalidex, also known as HDP-Tenofovir and CMX-157, is a highly potent prodrug of the antiviral tenofovir, appeared safe and well-tolerated in patients with hepatitis B, according to a presentation at The Liver Meeting 2017. Tenofovir exalidex results in decreased circulating levels, lowering systemic exposure and thereby reducing the potential for renal and bone side effects. |
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92562-88-4 |
LagociclovirLagociclovir is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. |
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92586-35-1 |
AZT triphosphateAZT triphosphate, an active triphosphate metabolite of Zidovudine (AZT), shows anti-retroviral activity, inhibits HIV replication, and also inhibits HBV DNA polymerase. It activates mitochondrial mediated apoptosis pathway. |
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942123-43-5 |
Inarigivir soproxilInarigivir soproxil is an orally active agonist of innate immunity that works via the RIG-I and NOD2 pathways. Inarigivir soproxil exhibits broad-spectrum antiviral activity against resistant HCV variants. |
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957011-15-3 |
HBF-0259HBF-0259 is a potent and selective hepatitis B virus (HBV) surface antigen (HBsAg) secretion inhibitor, with an EC50 of 1.5 μM in HepG2.2.15 cells. It has no effect on HBV DNA synthesis. |
|
99-93-4 |
4'-HydroxyacetophenoneAn Acetaminophen impurity. |
|
67-03-8 |
Thiamine hydrochlorideThiamine or vitamin B1 is a water-soluble vitamin of the B complex, its phosphate derivatives are involved in many cellular processes. |
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142217-69-4 |
EntecavirAn oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process. |
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1228585-88-3 |
GS 9620GS 9620 is a potent and oral agonist of TLR7. |
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65995-64-4 |
PunicalinPunicalin is an ellagitannin. It is a highly active carbonic anhydrase inhibitor with strong antioxidative activity. Punicalin have anti-hepatotoxic activity but the larger dose of punicalin induced liver damage. |
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