Arenavirus

Arenaviruses can cause severe haemorrhagic fever and neurological diseases in humans and other animals.

Cytomegalovirus (CMV)

Human cytomegalovirus is a member of the viral family known as herpesviruses, Herpesviridae, or human herpesvirus-5 (HHV-5).

Epstein-Barr Virus (EBV)

Many people become infected with EBV in childhood. EBV infections in children usually do not cause symptoms, or the symptoms are not distinguishable from other mild, brief childhood illnesses.

Enterovirus (EV)

Enteroviruses are small, nonenveloped, positive-sense, single-stranded RNA viruses with an icosahedral capsid.

Filovirus

Filoviruses is amongst the most lethal of primate pathogens. Filoviruses cause lethal hemorrhagic fever in humans and nonhuman primates.

Hepatitis B virus (HBV)

HBV is likewise a part of the Hepadnaviridae family of viruses， which can cause the disease hepatitis B.

Hepatitis C Virus (HCV)

The HCV protein NS5A prevents the apoptosis-enabling loss of intracellular potassium by inhibiting Kv2.1 function and thus blocking hepatocyte cell death.

HCV Protease

The NS3-4A serine protease of HCV has been one of the most attractive targets for developing specific antiviral agents against HCV.

Human Immunodeficiency Virus (HIV)

HIV is a lentivirus that causes the acquired immunodeficiency syndrome (AIDS).

HIV Protease

HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion.

Human Papillomavirus (HPV)

HPV displays tropism toward the epithelial basal layer, which houses adult epithelial stem cells responsible for replenishing the epithelium with daughter cells.

Herpes Simplex Virus (HSV)

HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons.

Influenza Virus

Influenza virus belongs to the Orthomyxoviridae group, which are enveloped, segmented, single-stranded negative sense RNA viruses.

Orthopoxvirus

The orthopoxvirus genus consists of 12 viruses including variola virus, vaccinia virus (VV), cowpox viruses (CV), monkeypox virus, and camelpox virus.

Reverse Transcriptases (RTs)

Reverse transcriptases are enzyme used to generate complementary DNA (cDNA) from an RNA template.

Respiratory Syncytial Virus (R S V)

R S V can exploit host immunity and cause a strong inflammatory response that leads to lung damage and virus dissemination.

SARS-CoV

SARS-CoV is the coronavirus (CoV) that causes severe acute respiratory syndrome (SARS).

Virus Protease

Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens.

Endogenous Metabolites

Endogenous metabolites can act as functional ligands, interacting with a wide range of proteins in vivo. Therefore, many small molecule antiviral drugs directly target endogenous metabolites in vivo.

HIF-HIF Prolyl-Hydroxylase

Hypoxia-inducible factor (HIF) prolyl hydroxylases are known as prolyl hydroxylase domain (PHD) enzymes and play an important role in the oxygen regulation of physiological networks.

HIV integrase

The development of new anti-HIV drugs targeting HIV integrase has become a hot spot for new drug development nowadays.

Others