Arenavirus

Arenaviruses can cause severe haemorrhagic fever and neurological diseases in humans and other animals.

Dengue virus

Dengue virus (DENV) belongs to the genus Flaviviridaeand is transmitted to humans by Aedes mosquitoes, mainly Aedes Egypt. Dengue virus can be classified into four types: DENV-1, DENV-2, DENV-3 and DENV-4.

Filovirus

Filoviruses is amongst the most lethal of primate pathogens. Filoviruses cause lethal hemorrhagic fever in humans and nonhuman primates.

Influenza Virus

Influenza virus belongs to the Orthomyxoviridae group, which are enveloped, segmented, single-stranded negative sense RNA viruses.

Nipah virus

Nipah virus (NiV) is a single-stranded negative-strand RNA virus belonging to the family Paramyxoviridae, a rare but extremely deadly pathogen that has been the focus of public health attention since it was first identified in Malaysia in 1998 due to its high lethality rate.

Rabies virus (RABV)

According to data released by the World Health Organization, rabies is endemic in 150 countries around the world, and 59,000 people die from rabies every year, and about 1 person dies of rabies every 9 minutes in the world, and 99% of these deaths are caused by dog bit es.

SARS-CoV

SARS-CoV is the coronavirus (CoV) that causes severe acute respiratory syndrome (SARS).

West Nile virus

West Nile virus (WNV) belongs to the genus Yellow Fever Virus of the Flaviviridae family, which belongs to Japanese encephalitis, St. Louis encephalitis, yellow fever, dengue fever, Japan encephalitis, hepatitis C and other viruses.

Enterovirus (EV)

Enteroviruses are small, nonenveloped, positive-sense, single-stranded RNA viruses with an icosahedral capsid.

Flavivirus

Flavivirus is an enveloped single-strand positive-strand RNA virus, which is transmitted by mosquito bit es and is an important pathogen of emerging infectious diseases, which seriously threatens human health.

Hepatitis C Virus (HCV)

The HCV protein NS5A prevents the apoptosis-enabling loss of intracellular potassium by inhibiting Kv2.1 function and thus blocking hepatocyte cell death.

Human Immunodeficiency Virus (HIV)

HIV is a lentivirus that causes the acquired immunodeficiency syndrome (AIDS).

Respiratory Syncytial Virus (R S V)

R S V can exploit host immunity and cause a strong inflammatory response that leads to lung damage and virus dissemination.

Cytomegalovirus (CMV)

Human cytomegalovirus is a member of the viral family known as herpesviruses, Herpesviridae, or human herpesvirus-5 (HHV-5).

Epstein-Barr Virus (EBV)

Many people become infected with EBV in childhood. EBV infections in children usually do not cause symptoms, or the symptoms are not distinguishable from other mild, brief childhood illnesses.

Hepatitis B virus (HBV)

HBV is likewise a part of the Hepadnaviridae family of viruses， which can cause the disease hepatitis B.

Herpes Simplex Virus (HSV)

HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons.

Human Papillomavirus (HPV)

HPV displays tropism toward the epithelial basal layer, which houses adult epithelial stem cells responsible for replenishing the epithelium with daughter cells.

Orthopoxvirus

The orthopoxvirus genus consists of 12 viruses including variola virus, vaccinia virus (VV), cowpox viruses (CV), monkeypox virus, and camelpox virus.

Tobacco mosaic virus (TMV)

In the late 19th century, it was known that a disease that threatened the survival of tobacco crops was first demonstrated by D.I. Iwanowski in 1892 that the disease was caused by a filtering pathogen, known as a virus.

Vesicular stomatitis virus (VSV)

Blistering stomatitis is an acute, highly contagious zoonotic infectious disease, especially in domestic animals such as horses, cattle and pigs. The disease is caused by the vesicular stomatitis virus and has been listed as one of the notifiable diseases under the International Office of Epizootics (OIE).

Endogenous Metabolites

Endogenous metabolites can act as functional ligands, interacting with a wide range of proteins in vivo. Therefore, many small molecule antiviral drugs directly target endogenous metabolites in vivo.

HCV Protease

The NS3-4A serine protease of HCV has been one of the most attractive targets for developing specific antiviral agents against HCV.

HIF-HIF Prolyl-Hydroxylase

Hypoxia-inducible factor (HIF) prolyl hydroxylases are known as prolyl hydroxylase domain (PHD) enzymes and play an important role in the oxygen regulation of physiological networks.

HIV integrase

The development of new anti-HIV drugs targeting HIV integrase has become a hot spot for new drug development nowadays.

HIV Protease

HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion.

Reverse Transcriptases (RTs)

Reverse transcriptases are enzyme used to generate complementary DNA (cDNA) from an RNA template.

Virus Protease

Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens.