Enterovirus (EV)

Enteroviruses are small, envelope-free, righteous, single-stranded RNA viruses with an icosahedral capsid. Infection with enteroviruses can cause various clinical symptoms, including poliomyelitis, meningitis and encephalitis, hand-foot-and-mouth disease, acute flaccid paralysis, diarrhea, myocarditis and respiratory illness. The nonstructural proteins of enteroviruses, particularly the protease 3C^pro and the RNA-dependent RNA polymerase 3D^pol, are attractive targets for antiviral drug development. Enteroviruses(EV) mainly include polioviruses, coxsackieviruses, echoviruses and novel enteroviruses with more than 100 serotypes. Enteroviruses can cause respiratory and neurological diseases, and are a major infectious disease that endangers human life and health. Currently, antiviral developments for EVs are mainly based on various molecular targets that interrupt viral attachment, viral translation, polyprotein processing and RNA replication.

Enteroviruses (EVs) are common human pathogens associated with different symptoms of disease in many organ systems of the body. EV infections usually cause mild or non-symptomatic disease, some of them are associated with serious illnesses such as central nervous system complications.

CAS No.	Product Name	Inquiry
2237925-62-9	DMA-135-hydrochloride DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies.
2413648-96-9	EV-A71-IN-1 EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an EC50 of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC50>56.2 μM).
2420396-84-3	Antiviral-agent-21 Antiviral agent 21 (Compound 4) is an anti-EV71 agent.
2519-30-4	Brilliant black Brilliant black BN, an azo dye and a food colorant, is a promising antiviral drug against EV71 infection by inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A.
2738376-73-1	Vapendavir-d5 Vapendavir-d5 is the deuterium labeled Vapendavir. Vapendavir (BTA798) is a potent enteroviral capsid binder (CB).
2749329-20-0	Pleconaril-d4 Pleconaril-d4 is deuterium labeled Pleconaril.
36284-77-2	Hederasaponin B Hederasaponin B inhibites the viral VP2 protein expression, suggesting the inhibition of viral capsid protein synthesis.
41312-47-4	3-Fucosyllactose 3-fucosyllactose is a trisaccharide that is lactose in which the hydroxy group at position 3 of the glucosyl moiety has undergone formal condensation with the anomeric hydroxy group of fucose (6-deoxy-L-galactose) to give the corresponding glycoside. It is one of the major fucosylated oligosaccharides found in human breast milkIt, and has a role as a human metabolite. It is functionally related to a lactose.
439085-51-5	Vapendavir Vapendavir is an orally active capsid-binding inhibitor as a capsid binderwith potent anti-rhinoviral activity and broad serotype coverage.
4443-09-8	Norwogonin Norwogonin is a flavonoid isolated from Scutellaria baicalensis Georgi, showing antiviral activity against Enterovirus 71 (EV71) with an IC50 of 31.83 μg/ml.
518-69-4	Corydaline Corydaline, an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. Corydaline exhibits the antiacetylcholinesterase, antiallergic, antinociceptive, and gastric emptying activities.
529-55-5	Prunin Prunin is a flavanone glycoside found in immature citrus fruits and in tomatoes. Its aglycone form is called naringenin. Prunin can not only inhibit protein tyrosine phosphatase 1B (PTP1B) but also stimulate glucose uptake in insulin-resistant HepG2 cells
60762-57-4	Pirlindole Pirlindole, a tetracyclic compound with potential antidepressant effect, is a selective reversible inhibitor of monoamine oxidase A.
61434-67-1	cis-Resveratrol Cis isomer of Resveratrol. Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi.
638-23-3	Carbocysteine Carbocisteine (INN), also called carbocysteine (USAN), is a mucolytic that reduces the viscosity of sputum and so can be used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis by allowing the sufferer to bring up sputum more easily. Carbocisteine should not be used with antitussives (cough suppressants) or medicines that dry up bronchial secretions.
740-33-0	Mosloflavone Mosloflavone is a flavonoid with anti-EV71 and promising anti-inflammatory activity.
7578-25-8	Lacto-N-fucopentaose I Lacto-N-fucopentaose I (LNFPI) is a human milk oligosaccharide (HMO), possessing antiviral and antibacterial activity. Lacto-N-fucopentaose I can reduce capsid protein VP1 to block virus adsorption, promote CDK2 and reduce cyclin E to recover cell cycle S phase block. Lacto-N-fucopentaose I inhibits ROS production and Apoptosis in virus-infected cells. Lacto-N-fucopentaose I can also regulate intestinal microbiota to affect immune system development.
86377-52-8	Ganoderic-acid-Y Ganoderic acid Y is a α-glucosidase inhibitor with an IC50 of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits enterovirus 71 (EV71) replication through blocking EV71 uncoating.
892128-60-8	LY2334737 LY2334737 is an orally available valproic acid ester of gemcitabine, which is a broad-spectrum antimetabolite with antineoplastic activity. It is an orally available prodrug of gemcitabine which is a nucleoside analog used as chemotherapy. It is hydrolyzed by carboxylesterase 2 (CES2) and releases gemcitabine systemically over a period of time consistent with formation rate-limited kinetics. It was less cytotoxic to a SK-OV-3 CES2 knockdown than parental cells.
950225-08-8	TTP-8307 TTP-8307, a potent inhibitor of several rhino- and enteroviruses replication, inhibits coxsackievirus B3 (CVB3; EC50 = 1.2 μM) and poliovirus by interfering with the synthesis of viral RNA, and exerts antiviral activity through oxysterol-binding protein (OSBP).

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