Human immunodeficiency Virus (HIV)

CAS No.	Product Name	Inquiry
1000287-05-7	TMC310911 TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity.
1015171-69-3	Methyl salvionolate A
1016260-22-2	Kadsuracoccinic acid A Kadsuracoccinic acid A is a natural compound isolated from the herb of Kadsura coccinea.
1018450-26-4	Fosdevirine Fosdevirine is a highly potent next-generation Anti-HIV nonnucleoside reverse transcriptase inhibitor (NNRTI) with an EC50 of 11 nM. It is a novel and once-daily (QD) inhibitor with activity against efavirenz-resistant strains. It demonstrated potent antiviral activity in treatment-naive HIV-infected subjects, and had favorable PK and resistance profiles. It was originally developed by idenix pharmaceuticals and was in clinical phase 2, but now it has been terminated.
1020719-94-1	rac-Tenofovir-[d6] One isotopotic labelled form of Tenofovir, which is an analogue of acyclic phosphonate nucleotide and could be used in antiviral treatment as an everse transcriptase inhibitor.
1025023-04-4	periglaucine A Periglaucine A is a natural alkaloid extracted from the aerial parts of Pericampylus glaucus, it can inhibit hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells.
103337-74-2	Letrazuril Letrazuril is an anti-HIV agent. It is also an antiprotozoal agent that is effective against cryptosporidium infections.
1033699-22-7	Maraviroc-[d6] Maraviroc-[d6] is the labelled analogue of Maraviroc. Maraviroc is an antiretroviral medicine developed for the treatment of HIV infecions.
1033950-94-5	HIV-1-inhibitor-32 HIV-1 inhibitor-32 (compound 3c) is a potent HIV-1 inhibitor with an IC50 value of 34 nM for WT HIV-1. HIV-1 inhibitor-32 can be used for researching AIDS.
104264-80-4	Manzamine A hydrochloride Manzamine A hydrochloride is an orally active beta-carboline alkaloid that has specific inhibitory effects on GSK-3β and CDK-5 with IC50s of 10.2 and 1.5 μM, respectively. It targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. It has potent activity against HSV-1, and has antimalarial and anticancer activities.
1044870-39-4	RVX-208 RVX-208 is a potent inhibitor of BET bromodomains. RVX-208 functions by removing atherosclerotic plaque via reverse cholesterol transport (RCT). RVX-208 increases the production of ApoA-I in hepatocytes in vitro, and in vivo in monkeys and humans, which results in increased HDL-C, but the molecular target was not previously reported. Using binding assays and X-ray crystallography, we now show that RVX-208 selectively binds to bromodomains of the BET (Bromodomain and Extra Terminal) family, competing for a site bound by the endogenous ligand, acetylated lysine, and that this accounts for its pharmacological activity. siRNA experiments further suggest that induction of ApoA-I mRNA is mediated by BET family member BRD4. These data indicate that RVX-208 increases ApoA-I production through an epigenetic mechanism and suggests that BET inhibition may be a promising new approach to the treatment of atherosclerosis.
1051418-95-1	Nevirapine-[d4] Nevirapine-[d4] is the labelled analogue of Nevirapine, which is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
1051419-24-9	Nevirapine-[d3] Nevirapine-[d3] is the labelled analogue of Nevirapine. Nevirapine is an anti-HIV drug that reduces the amount of virus in the body.
1054312-81-0	FK-3000
106060-92-8	AZT triphosphate tetraammonium
106362-32-7	Peptide T Peptide T is an HIV entry inhibitor that acts by blocking chemokine-5 receptors (CCR5), currently under clinical trials for the treatment of HIV-related neurological and constitutional symptoms.
106362-34-9	Adaptavir A CCR5 receptor antagonist. CCR5 antagonists block HIV from getting into and infecting certain cells of the immune system.
1067224-41-2	Epicoccone B Epicoccone B, a natural product firstly reported from C. globosum, has anti-HIV activity. It has the ability of scavenging DPPH free radical with an IC50 of 10.8 μM, and has strong inhibitory effect on α-glucosidase with an IC50 of 27.3 μM.
1069-66-5	Sodium valproate Valproic acid is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
1073897-80-9	1,3,5-tricaffeoylquinic acid 1,3,5-Tricaffeoylquinic acid is a tricaffeoylquinic acid derivative isolated from H. populifolium with anti-HIV effect.

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