Antiviral Drug Characterization
A thorough characterization of the physical and chemical properties of antiviral drugs is a regulatory requirement as well as an important step in drug development. Physicochemical characterization is critical to both the project economics and timeline. The quality of the product be well controlled throughout the process with a thorough understanding of the drug's properties. In general, the characterization of antiviral drugs is evaluated mainly by applying nuclear magnetic resonance (NMR) and liquid chromatography-high resolution mass spectrometry (LC-HRMS) method. NMR spectroscopy is an analytical chemistry technique that determines purity and molecular structure of antiviral drug. LC-HRMS can be used to determine elemental composition and distinguish between different molecules. Recently, the molecular structures of five antiviral drugs: remdesivir, ebastine, bepridil, rupintrivir and colchicine, have been characterized successfully to advance the registration process for new drugs.
At BOC Sciences, our state-of-the-art instrumentation combined with the expertise of our highly qualified scientists provides you with a comprehensive understanding of the physicochemical properties of antiviral drugs.
Figure 1. Physicochemical Characterization of Cyclodextrin-Drug Interactions in the Solid State. (Ogawa, N.; et al. 2015)
Comprehensive Drug Characterization Services
We can utilize the latest chromatographic and spectroscopic techniques to establish the most effective methods for structure elucidation and evaluation, and are able to provide complete physicochemical characterization.
- Molecular characterization
At BOC Sciences, we can fully characterize the molecular properties of your antiviral drug in a variety of solvents and under different conditions, including:
- pKa
- LogP/LogD
- Turbidimetric solubility
- Thermodynamic equilibrium solubility in water, organic solvents, buffers, formulation solvents, simulated body fluids
- Chemical stability in solution (temperature, pH, hydrolysis, oxidation, photocatalytic degradation)
- Compatibility of excipients
- Molecular structure confirmation
The structure of an antiviral drug substance determines the disease targets with which it can interact, and thus its therapeutic function. Our experts perform molecular structure conformation using various techniques to confirm the molecular structure of the antiviral drug.
- Elemental analysis
- Chromatography
- Nuclear magnetic resonance spectroscopy
- Mass spectrometry
- Infrared/UV-Vis spectroscopy
- X-ray powder diffraction
- Single crystal X-Ray diffraction
Figure 2. Identification and characterization of the intramolecular interaction. (Rodrigues. D. A.; et al. 2020)
- Powder characterization
We can apply a variety of technologies to analyze powder properties, including:
- Volume and vibronic density
- Flow characteristics testing
- Odor and color
- Static electricity
- Compression properties
- Compaction properties
- Milling, grinding and granulation (chemical-physical stability)
- Solid state properties
Solid-state characterization is key to understanding the physical properties of antiviral drugs. Our capabilities include:
- Characterization of selected forms (salt or neutral forms) - DSC, TGMS, high temperature super-nuclear meters, XRPD, Fourier transform infrared/Raman spectroscopy
- Stability stress studies including temperature/humidity, photostability - climate chambers, XRPD with thermal humidity stages, DVS, TGMS
- Karl Fischer
- Crystal habit microscopy, particle size and shape, surface area
- Dissolution behavior (intrinsic dissolution)
- Common ionic effects
Why Partner with BOC Sciences?
- We apply our years of proven expertise and experience in antiviral drug development to improve the success of your program
- Our continuously updated facilities support a range of antiviral drug analysis and manufacturing services
- BOC Sciences' experienced team of scientists and regulatory staffs are focused on working with our clients to deliver timely and high-quality small molecule antiviral drugs
- Our partnerships with leading experts in emerging technologies allow us to apply innovative solutions to your antiviral drug research programs
References
- Ogawa, N.; et al. Physicochemical Characterization of Cyclodextrin-Drug Interactions in the Solid State and the Effect of Water on These Interactions. Journal of Pharmaceutical Sciences. 2015. 104(3): 942-954.
- Rodrigues. D. A.; et al. Structure-property relationship studies of 3-acyl-substituted furans: the serendipitous identification and characterization of a new non-classical hydrogen bond donor moiety. New Journal of Chemistry. 2020. 44.
※ Please kindly note that our services are for research use only.
