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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Abacavir
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 136470-78-5 |
| Description | Abacavir sulfate is a Nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS. |
Product Information
| Synonyms | Ziagen |
| Molecular Weight | 286.33 |
| Molecular Formula | C14H18N6O |
| Canonical SMILES | C1CC1NC2=NC(=NC3=C2N=CN3C4CC(C=C4)CO)N |
| InChI | InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1 |
| InChIKey | MCGSCOLBFJQGHM-SCZZXKLOSA-N |
| Boiling Point | 636.0±65.0 °C at 760 mmHg |
| Melting Point | 161 °C(dec.) |
| Flash Point | 338.4±34.3 °C |
| Purity | >98% |
| Density | 1.7±0.1 g/cm3 |
| Solubility | In Vitro: DMSO: ≥ 3 mg/mL (10.48 mM) |
| Appearance | White to off-white (Solid) |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 414 |
| Exact Mass | 286.15420922 |
| Index Of Refraction | 1.864 |
| In Vitro | Abacavir (15 and 150 μM, 0-120 h) inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines, and it significantly reduces cell migration and inhibits cell invasion. |
| In Vivo | Abacavir (100 and 200 mg/kg, p.o.; 4 h) dose-dependently promoted thrombus formation, and enhances survival of high-risk medulloblastoma-bearing mice. |
| PSA | 101.88000 |
| Target | HIV; Reverse Transcriptase; Telomerase; Apoptosis |
| Vapor Pressure | 0.0±2.0 mmHg at 25°C |
| XLogP3-AA | 0.9 |
