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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
Human immunodeficiency Virus (HIV)
Currently, HIV cannot be completely eliminated, and the most common treatment option is highly active anti-retroviral therapy (HAART). There are more than 30 drugs (including combination agents) in 6 major categories on the market, namely nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), integrase inhibitors (INSTIs), membrane fusion inhibitors (FIs) and CCR5 inhibitors. The major antiretroviral drugs available are Tenofovir-disoproxil (TDF); Abacavir (ABC); Lamivudine (3-TC); Emtricitabine (FTC); Propofol tenofovir (TAF); Zidovudine (AZT); Doravirine (DOR); Bictegravir (BIC); Efavirenz (EFV); lopinavir/Ritonavir (LPV/r); Raltegravir ( RAL); Nevirapine (NVP); Rilpivirine (RBV).
Human immunodeficiency virus (HIV) is a lentivirus that causes the acquired immunodeficiency syndrome (AIDS). HIV invades the body and destroys the body's immune system, causing the infected person to gradually lose the ability to fight various diseases and eventually lead to death.
CAS No. | Product Name | Inquiry |
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88515-58-6 |
RosamultinRosamultin is a natural compound isolated from the roots of Rosa rugosa. |
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90344-84-6 |
5-Fluorouracil-[6-d]5-Fluorouracil-d1 (5-FU-d1) is the deuterium labeled 5-Fluorouracil. It is an analogue of uracil and apotent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
|
90-45-9 |
9-Aminoacridine9-Aminoacridine is a highly fluorescent dye, an acridine analog. It is used clinically as a topical antiseptic and experimentally as a mutagen. It is an intracellular pH indicator and a DNA intercalating agent. |
|
911208-73-6 |
Tenofovir exalidexTenofovir exalidex, also known as HDP-Tenofovir and CMX-157, is a highly potent prodrug of the antiviral tenofovir, appeared safe and well-tolerated in patients with hepatitis B, according to a presentation at The Liver Meeting 2017. Tenofovir exalidex results in decreased circulating levels, lowering systemic exposure and thereby reducing the potential for renal and bone side effects. |
|
912809-27-9 |
Rovafovir-etalafenamideRovafovir etalafenamide (GS-9131), a prodrug of the adenosine nucleotide analogue GS-9148, is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Rovafovir etalafenamide is potent and active against a variety of NRTI mutants, and shows potent anti-HIV-1 activity. |
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914454-00-5 |
Enfuvirtide AcetateEnfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide. |
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916489-36-6 |
MS417MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM). |
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920036-04-0 |
HIV-1-inhibitor-31HIV-1 inhibitor-31 (compound 4) is a potent HIV-1 inhibitor. HIV-1 inhibitor-31 can be used for researching AIDS. |
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92586-35-1 |
AZT triphosphateAZT triphosphate, an active triphosphate metabolite of Zidovudine (AZT), shows anti-retroviral activity, inhibits HIV replication, and also inhibits HBV DNA polymerase. It activates mitochondrial mediated apoptosis pathway. |
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934740-33-7 |
NifevirocNifeviroc is a CCR5 antagonist that can be used to treat HIV type 1 infection. |
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950913-56-1 |
EFdA-TPEFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits HIV-1 RT with multiple mechanisms. |
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960055-56-5 |
Panobinostat-lactatePanobinostat lactate is a potent and orally active non-selective HDAC inhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disrupts HIV latency. Panobinostat lactate induces cell Apoptosis and Autophagy. |
|
960374-59-8 |
ONX-0914ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome. Recent evidence suggests that the immunoproteasome regulates the production of several inflammatory cytokines, including Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), IL-17, and IL-23. In preclinical models of rhematoid arthritis and lupus, ONX 0914 blocked progression of these diseases at well-tolerated doses. Preclinical studies are underway to evaluate the potential of ONX 0914 in the treatment of a range of autoimmune disorders. |
|
99-24-1 |
Methyl gallateMethyl gallate isolated from the herbs of Sapium sebiferum. It is a reverse transcriptase inhibitor. |
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99-66-1 |
Valproic acidValproic acid is an inhibitor of histone deacetylase (HDAC) inhibitor, which has an anticancer effect. Valproic acid was shown to induce proliferation and enhance self-renewal of hematopoietic stem cells (HSC). |
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517-89-5 |
(R)-Shikonin(R)-Shikonin is a naphthoquinone extracted from Lithospermum erythrorhizon and Alkanna sp. It is a natural cardioprotective, antioxidative and anti-inflammatory agent. |
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146426-40-6 |
AlvocidibAlvocidib is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. |
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159989-65-8 |
Nelfinavir MesylateNelfinaviris a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor. |
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1228585-88-3 |
GS 9620GS 9620 is a potent and oral agonist of TLR7. |
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1135695-98-5 |
Q-VD-OPHQVD-OPH, also known as Quinoline-Val-Asp-Difluorophenoxymethylketone, is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 (IC50 = 25nm), caspase-1 (IC50 = 50nM), caspase-8 (IC50 = 100nM) and caspase-9 (IC50 = 430nM). It can be used in Alzheimer's studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor. |
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