Respiratory syncytial Virus (RSV)

Overview

RSV is a major cause of acute respiratory infections. RSV can exploit host immunity and cause a strong inflammatory response leading to lung damage and virus dissemination. Researchers have found that inflammation is an important part of severe RSV disease, suggesting that treating severe RSV disease with antiviral drugs together with anti-inflammatory therapy may ease discomfort and help patients recover more quickly. In addition, there are experimental results suggesting a possible role of the anti-influenza drug oseltamivir in treating RSV infection.

CAS No.	Product Name	Inquiry
1963-36-6	para-METHOXY CINNAMIC ALDEHYDE (PMCA) 4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. It effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 μg/mL.
2151937-80-1	AVG-233 AVG-233 is a potent, orally active RNA dependent RNA polymerase (RdRp) inhibitor. AVG-233 prevents initiation of the viral polymerase complex at the promoter. AVG-233 binding site is present in the L1-1749 fragment. AVG-233 has nanomolar activity against both RSV strains and clinical RSV isolates (EC50=0.14-0.31 μM). AVG-233 can be used for research of respiratory syncytial virus (RSV).
2395007-75-5	RSV-IAV-IN-2 RSV/IAV-IN-2 (compound 14c) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-2 has lesser cytotoxicity than the clinical drug, Ribavirin. RSV/IAV-IN-2 has the potential for the research of RSV and/or IAV infections.
2395007-77-7	RSV-IAV-IN-1 RSV/IAV-IN-1 (compound 14e) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-1 has lesser cytotoxicity than the clinical drug, Ribavirin. RSV/IAV-IN-1 has the potential for the research of RSV and/or IAV infections.
2395007-81-3	RSV-IAV-IN-3 RSV/IAV-IN-3 (compound 14'i) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza A virus (IAV) with EC50 values of 2.92 µM and 1.90 µM,respectively. RSV/IAV-IN-3 has antiviral effect against H1N1 and H3N2 with EC50 values of 3.25 µM and 1.50 µM in MDCK cells, respectively. RSV/IAV-IN-3 significantly inhibits the activity of luciferase in a dose-dependent manner, with an EC50 of 3.89 µM. RSV/IAV-IN-3 inhibits IAV infectivity and RdRp activity. RSV/IAV-IN-3 inhibits IAV and RSV replication at the post-entry stage.
2415018-86-7	RSV-IN-5 RSV-IN-5 (Compound 4) is a potent dual inhibitor of wild-type and mutant respiratory syncytial virus (RSV) fusion proteins.
2415152-41-7	RSV-IN-6 RSV-IN-6 (Compound 53) is an anti-RSV agent targeting M2-1 protein with EC50 values of 4.4 μM and 1.3 μM against RSV-A and RSV-B strain, respectively.
2448519-26-2	RSV-IN-2 RSV-IN-2 is a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins.
2711039-08-4	ACSS2-IN-1 ACSS2-IN-1 is a potent ACSS2 inhibitor used in the treatment of cancer.
312615-62-6	Antiviral agent 10 Antiviral agent 10 is an antiviral agent and it can inhibit respiratory syncytial virus (RSV).
317846-22-3	JNJ-2408068 JNJ-2408068 is a potent inhibitor of respiratory syncytial virus (RSV), exhibits potent antiviral activity with 50% effective concentrations (EC50s) of 1.4 and 2.1 nM, respectively.
3886-39-3	RD3-0028 RD3-0028 is a potent and selective inhibitor of RSV replication with EC50 value of 4.5 μM.
508186-14-9	Ac-CoA Synthase Inhibitor 1 Ac-CoA Synthase Inhibitor 1 is an anti-virus agent.
676128-62-4	RSV604 racemate RSV604 racemate is a racemic mixture of RSV604, an inhibitor of respiratory syncytial virus (RSV) replication. The racemate is less potent than the S-isomer.
676128-63-5	RSV604 RSV604 is a a novel benzodiazepine with submicromolar anti-RSV activity (EC50=0.86 uM).
857066-90-1	TMC353121 TMC353121 is a potent RSV fusion inhibitor. Its activity profile was found to be identical to the profile of JNJ-2408068.
861139-16-4	RSV-IN-1 RSV-IN-1 is a human respiratory syncytical virus (hRSV) inhibitor with IC50 value of 0.11 μM.
862825-89-6	RSV-IN-4 RSV-IN-4 (Compound 2) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-4 shows anti-RSV activity (EC50 = 11.76 μM).
862825-90-9	RSV-IN-3 RSV-IN-3 (Compound 1) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-3 shows anti-RSV activity (EC50 = 32.70 μM).
932108-20-8	RSV604 R enantiomer RSV604 R enantiomer is the R-enantiomer of RSV604, an inhibitor of respiratory syncytial virus (RSV) replication. R-enantiomer is less active against RSV compared to RSV604.

※ Please kindly note that our services are for research use only.