2-Cyclopentene-1-methanol,4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-,hydrochloride (1:1), (1S,4R)-

Category	Human immunodeficiency Virus (HIV)
CAS	136777-48-5
Description	Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. It can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses telomerase activity.

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Synonyms	ABACAVIR SULPHATE; ZIAGEN; ((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enyl)methano; Abacavir & Abacavir Sulfate
IUPAC Name	[(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol
Molecular Weight	286.33
Molecular Formula	C14H18 N6 O . Cl H
Canonical SMILES	C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.Cl
InChI	InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1
InChIKey	MCGSCOLBFJQGHM-SCZZXKLOSA-N
Purity	>98%
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	414
Exact Mass	322.1308869
In Vitro	Abacavir hydrochloride (15 and 150 μM, 0-120 h) inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines. It significantly reduces cell migration and inhibits cell invasion, and induces fat Apoptosis.
In Vivo	Abacavir hydrochloride (100 and 200 mg/kg, p.o.; 4 h) dose-dependently promotes thrombus formation. Abacavir hydrochloride (50 mg/kg/d; i.p.; 14 d) with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice.
PSA	102.61000
Target	HIV; Apoptosis; Reverse Transcriptase; Telomerase