Influenza Virus

In general, influenza viruses include three types of influenza viruses, A, B and C. Types B and C viruses only infect humans, but the type A viruses infect humans, horses, swine, other mammals and a variety of domesticated and wild birds. Human influenza A and B viruses cause seasonal disease epidemics worldwide almost every winter. Influenza type C infections causes a mild respiratory illness. Currently, there are four FDA-approved influenza antiviral drugs used to treat the recent influenza viruses: Rapivab (paramivir), Relenza (zanamivir), Tamiflu (oseltamivir phosphate, also available as a generic) and Xofluza (baloxavir maboxil).

Influenza is a disease caused by influenza viruses. Different illnesses cause different flu-like symptoms such as fever, chills, aches and pains, cough and sore throat. Influenza virus infections can cause different patterns of illness, ranging from mild common cold symptoms to typical flu. Some people may be at increased risk for developing bacterial complications of the flu, such as pneumonia, ear or sinus infections or bloodstream infections.

CAS No.	Product Name	Inquiry
78842-13-4	2'-Deoxy-2'-fluoroguanosine It is an influenza viral polymerase inhibitor like Ribavirin, used as an antiviral drug against avian (H5N1) influenza virus.
84-79-7	Lapachol a reagent used in the synthesis of B-Lapachones for use in anti-proliferative tumor studies.
862825-89-6	RSV-IN-4 RSV-IN-4 (Compound 2) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-4 shows anti-RSV activity (EC50 = 11.76 μM).
862825-90-9	RSV-IN-3 RSV-IN-3 (Compound 1) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-3 shows anti-RSV activity (EC50 = 32.70 μM).
862893-75-2	Ganoderic-acid-TR Ganoderic acid TR is a broad-spectrum inhibitor against influenza neuraminidases (NAs), particularly H5N1 and H1N1 neuraminidases. The IC50 values of 10.9 and 4.6 μM, respectively.
86582-98-1	N-Acetylneuraminic-acid-d3 N-Acetylneuraminic acid-d3 is the deuterium labeled N-Acetylneuraminic acid. N-Acetylneuraminic acid is a nine-carbon, sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies suggest that N-Acetylneuraminic acid is useful biologically in neurotransmission, leukocyte extravasation, viral or bacterial infections and carbohydrate-protein recognition.
88-04-0	Chloroxylenol Chloroxylenol is an antimicrobial preservative and germicide, as well as a disinfectant for skin and wounds. Chloroxylenol is a drug used to treat acne vulgaris, infected root canals, and as an antifungal agent.
890842-28-1	GSK650394 GSK650394 is a competitive inhibitor that quantitatively blocks the effect of androgens on LNCaP cell growth.
90-47-1	Xanthone Xanthonoid Purified from Hypericum perforatum.
9087-70-1	Aprotinin Aprotinin is the small protein bovine pancreatic trypsin inhibitor (BPTI). It is an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes. It is a competitive serine protease inhibitor which blocks the active sites of enzyme by forming stable complexes with. It is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges. It is used as a medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. It is used clinically to prevent postoperative blood loss and reduce transfusion requirements in those procedures which employ extracorporeal circulation. It is also used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest. It was temporarily withdrawn worldwide in 2007. It was reverted its previous standpoint regarding aprotinin by the European Medicines Agency (EMA) scientific committee in February 2012.
913822-46-5	SC75741 SC75741 is a potent NF-κB inhibitor (EC50=200 nM).
91-64-5	Coumarin Coumarin is an edema modifier, known to stimulate macrophages to degrade extracellular albumin, allowing faster resorption of edematous fluids. It has anti-cancer, anti-inflammation, anti-virus and other pharmacological activities.
928659-17-0	Triazavirin Triazavirin is a broad-spectrum antiviral drug, effective against various strains of the Influenza A virus. Triazavirin inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin might be a potential treatment for SARS-CoV-2.
932-53-6	6-Azathymine 6-Azathymine, a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor, inhibits DNA biosynthesis and has antibacterial and antiviral activities.
95258-13-2	Yadanziolide B Yadanziolide B is extracted from the seeds of Brucea javanica. It displays cytotoxic activities with IC50 values in the range of 3.00-5.81 uM.
959245-08-0	CBS1117 CBS1117 is an effective inhibitor of influenza A virus entry, which can inhibit influenza virus hemagglutinin.
133550-34-2	AG 555 AG 555 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC50 = 0.7 μM) with 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively.
153436-53-4	AG-1478 AG-1478 (NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM; almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.
10537-47-0	Tyrphostin 9 Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM.
170449-18-0	AG 1478 hydrochloride The hydrochloride salt form of AG 1478, which has been found to be an epidermal growth factor receptor tyrosine kinase inhibitor.

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