Herpes simplex Virus (HSV)

As neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. Currently, drugs targeting different stages of herpesvirus replication are being developed. There are several medicines targeting herpesvirus DNA replication, including non-nucleoside inhibitors of viral DNA polymerase and helicase–primase inhibitors show considerable promise.

Herpes simplex virus (HSV) can be spread when an infected person produces and sheds the virus. HSV causes a variety of important diseases, and symptoms of HSV infection include watery blisters in the skin or mucous membranes of the mouth, lips, or genitals. There are many antiviral drugs with activity against HSV-1 and HSV-2. These medicines include acyclovir, famciclovir and valacyclovir.

CAS No.	Product Name	Inquiry
6153-64-6	Oxytetracycline dihydrate It is the second of the broad-spectrum tetracycline group of antibiotics to be discovered. Oxytetracycline works by interfering with the ability of bacteria to produce essential proteins. It is an antibacterial isolated from the elaboration products of the actinomycete, Streptomyces rimosus.
661-19-8	1-Docosanol Docosanol is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement.
66341-16-0	Acyclovir-5'-monophosphate Acyclovir-5'-monophosphate is a nucleotide analog that has the potential to treat herpes virus infections.
667463-85-6	BIO-acetoxime BIO-acetoxime is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. It shows >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B. It has anticonvulsant and anti-infection activity.
69657-51-8	Sodium 2-Amino-9-[(2-hydroxyethoxy)methyl]purin-6-olate Sodium 2-Amino-9-[(2-hydroxyethoxy)methyl]purin-6-olate (CAS# 69657-51-8 ) is a useful research chemical.
69-74-9	Cytarabine hydrochloride Cytarabine, an antimetabolite analogue of cytidine with a modified sugar moiety, is an antimetabolic agent and DNA synthesis inhibitor.
70-00-8	Trifluridine Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA.
70288-86-7	Ivermectin Ivermectin is a glutamate-gated chloride channel (GluCls) activator, which is used as an antiparasitic drug for the treatment of certain parasitic roundworm infections. Ivermectin inhibits the chloride channels of helminthic parasites and has been shown to have clinical efficacy for the treatment of onchocerciasis, strongyloidiasis, and ectoparasitic infection. Ivermectin is a mixture of mostly Ivermectin B1a (>80%) with some Ivermectin B1b (<20%), which are macrolides from Streptomyces avermitilis.
80685-22-9	9-Carboxymethoxymethylguanine 9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir, which is an orally active antiviral drug.
82410-32-0	Ganciclovir Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM.
84558-93-0	Netivudine Netivudine, a nucleoside analogue, has potent anti-varicella zoster virus activity.
867-44-7	S-Methylisothiourea hemisulfate salt (S)-Methylisothiourea sulfate is a more potent than NMMA as an inhibitor of inducible nitric oxide synthetase (iNOS). The Ki values are 120, 200, and 160 nM using purified human iNOS, eNOS, and nNOS, respectively.
88901-43-3	Mogroside III-A2 Mogroside III-A2 is found in Siraitia grosvenorii.
896106-16-4	Imiquimod maleate Imiquimod maleate is an immune response modifier. It acts as a toll-like receptor 7 agonist. It is commonly used topically to treat warts on the skin of the genital and anal areas. It is also used to treat certain diseases of the skin, including skin cancers, such as basal cell carcinoma, Bowen's disease, superficial squamous cell carcinoma, some superficial malignant melanomas, and actinic keratosis. It can lead to the activation of Langerhans cells, which subsequently migrate to local lymph nodes to activate the adaptive immune system when applied to skin.
9061-39-6	Galactofucan Galactofucan (Fucogalactan) is a sulfated polysaccharide. Galactofucan can be extracted from brown seaweed Saccharina longicruris with anticoagulant, anti-tumor, anti-thrombosis, anti-inflammatory and antiviral properties. Galactofucan shows antiviral activities to HSV-1 and HSV-2 with IC50s of 0.76 and 1.34 µg/mL, respectively. Galactofucan can be used for the research of cancer and inflammation.
957890-42-5	HIV-1 integrase inhibitor 2 HIV-1 integrase inhibitor 2 is useful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. It did not affect integrase-DNA binding and only weakly inhibited the catalytic activities of integrase.
96412-41-8	Guanosine-8-d Guanosine-8-d is a deuterium labeled Guanosine. Guanosine is a purine nucleoside comprising guanine attached to a ribose(ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.
97845-62-0	Penciclovir sodium Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse
99011-78-6	Imiquimod hydrochloride Imiquimod hydrochloride is an immune response modifier. It acts as a toll-like receptor 7 agonist. It is commonly used topically to treat warts on the skin of the genital and anal areas. It is also used to treat certain diseases of the skin, including skin cancers, such as basal cell carcinoma, Bowen's disease, superficial squamous cell carcinoma, some superficial malignant melanomas, and actinic keratosis. It can lead to the activation of Langerhans cells, which subsequently migrate to local lymph nodes to activate the adaptive immune system when applied to skin.
16595-80-5	Levamisole hydrochloride Levamisole hydrochloride, the hydrochloride salt of a water-soluble imidazothiazole derivative, selectively activates acetylcholine receptor ion channels in nerve and muscle of nematodes (EC50 = 6 µM). It has anthelminthic and immunomodulating activities.

※ Please kindly note that our services are for research use only.