Virus Protease

Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens that catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. different catalytic mechanisms are used by viral proteases which include srine, cysteine or aspartic acid residues to attack the cleaved peptide bond. The initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2), is critical for entry of SARS-CoV-2. Furthermore, the success of anti-HIV-1 therapy using specific protease inhibitors suggests that viral proteases can be effective molecular targets for the development of other antiviral drugs.

Proteases play multiple roles in health and disease, and researchers have expressed great interest in the design and development of inhibitors of the synthesis of disease-related proteases. Virus-encoded proteases have been shown to be involved in the replication of many viruses.

CAS No.	Product Name	Inquiry
432499-63-3	4E2RCat 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
482646-13-9	A2ti-2 A2ti-2 is a selective and low-affinity inhibitor of annexin A2/S100A10 heterotetramer (A2t) with an IC50 of 230 μM. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. It protects against human papillomavirus type 16 (HPV16) infection.
50-78-2	Aspirin Aspirin is a salicylate and irreversible COX1 and COX2 inhibitor. It can be used for the treatment of fever, rheumatism, nerve, muscle, joint pain, soft tissue inflammation and gout in animals.
523-50-2	Angelicin Photosensitizing; used for determining DNA/RNA structures in cells and microorganisms. Furocoumarin , from plants of the Psoralea genus, Leguminosae.
537049-40-4	Tubacin Tubacin was used to study the role of HDAC6 in migration and invasion of bladder cancer cells. Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM.
552-98-7	Lithium O-acetylsalicylate Aspirin (Acetylsalicylic Acid) lithium is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin lithium induces Apoptosis. Aspirin lithium inhibits the activation of NF-κB. Aspirin lithium also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.
570390-00-0	A2ti-1 A2ti-1 is a selective and high-affinity inhibitor of annexin A2/S100A10 heterotetramer (A2t) with an IC50 of 24 μM. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. It protects against human papillomavirus type 16 (HPV16) infection.
60-12-8	2-Phenylethanol 2-Phenylethanol is used as an antibacterial preservative in nasal, ophthalmic, and otic preparations. It is also used in flavors and as a perfumery component, especially in rose perfumes.
702662-50-8	STING agonist-1 STING agonist-1 (G10) is a novel human-specific STING agonist (IC90 = 24.57 μM), exhibits no direct binding affinity for STING
790702-57-7	NGI 1 NGI 1 is a cell-permeable oligosaccharyltransferase (OST) inhibitor. It exhibits a potent activity against flaviviruses via blocking viral RNA replication. It also selectively arrests proliferation of non-small-cell lung cancer cells that are dependent on EGFR or FGFR for survival.
84-65-1	Anthraquinone Anthraquinone is used in dye manufacturing, the textile and pulp industries, and as a bird repellant.
910582-16-0	ZIKV-IN-2 ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV).
921943-73-9	Acetylsalicylic Acid-[d3] Acetylsalicylic Acid-[d3] is the labelled analogue of Acetylsalicylic Acid, which is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of pains and inflammations.
940908-79-2	R-7128 R-7128 is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all HCV genotypes. It is a nucleoside polymerase inhibitor (NPI) and is able to inhibit the RNA synthesis of HCV in vitro.
947699-46-9	ZIKV-IN-3 ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV).
96-50-4	2-Aminothiazole Aminothiazole can be used as a thyroid inhibitor and it has antibacterial activity.
97781-16-3	Acetylsalicylic Acid-[d4] Acetylsalicylic Acid-[d4] is the labelled analogue of Acetylsalicylic Acid, which is an antithrombotic, anti-inflammatory, antipyretic analgesic. Acetylsalicylic Acid is an inhibitor of Cox-1 and Cox-2.
98-98-6	2-Picolinic acid Picolinic acid is a metabolite of tryptophan that acts as an anti-infective and immunomodulator. It is produced under inflammatory conditions.
905586-69-8	AZ-960 AZ-960 is an ATP-competitive inhibitor of JAK2 with Ki value of 0.45 nM. It inhibits proliferation in a SET-2 human megakaryoblastic cell line harboring the JAK2V617F mutation with GI50 value of 33 nM.
2248666-66-0	PF 429242 dihydrochloride PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. It reduces hepatic synthesis of cholesterol and fatty acid in mice.

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