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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
TOPOTECAN(TPT)
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 139339-45-0 |
| Description | Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects. |
Product Information
| Synonyms | 139339-45-0|Ro 24-7429|Ro-24-7429|7-Chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine|Ro24-7429|MLW2GKK8LI|UNII-MLW2GKK8LI|478511-16-9|3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-|7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-1,3-dihydro-1,4-benzodiazepin-2-imine|7-Chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-benzo[e][1,4]diazepin-2-amine|TOPOTECAN(TPT)|PhlegmanolC|MLS003370633|SCHEMBL2050520|ZINC5304|CHEMBL2360841|CHEBI:93522|DTXSID20161021|ML223|EX-A5722|NCGC00185960-02|NCGC00188362-01|NCGC00188362-02|NCGC00188362-03|HY-19149|SMR002044722|CS-0014889|FT-0699551|Q27165217 |
| IUPAC Name | 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-1,3-dihydro-1,4-benzodiazepin-2-imine |
| Molecular Weight | 272.73300 |
| Molecular Formula | C14H13ClN4 |
| Canonical SMILES | CN=C1CN=C(C2=C(N1)C=CC(=C2)Cl)C3=CC=CN3 |
| InChI | InChI=1S/C14H13ClN4/c1-16-13-8-18-14(12-3-2-6-17-12)10-7-9(15)4-5-11(10)19-13/h2-7,17H,8H2,1H3,(H,16,19) |
| InChIKey | LEAKQIXYSHIHCW-UHFFFAOYSA-N |
| Boiling Point | 514.6°C(760mmHg),calc. |
| Flash Point | 265°C |
| Purity | 95% |
| Density | 1.36g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | White to yellow (Solid) |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 393 |
| Exact Mass | 272.0828741 |
| In Vitro | Ro 24-7429 (0.1-5 μM; 3 days) induces Apoptosis of cultured PBMCs in a dose-dependent manner. Ro 24-7429 (1-25 μM) also induces Apoptosis and inhibits antigen-induced lymphocyte proliferation Ro 24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro 24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours. |
| In Vivo | Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs. |
| PSA | 52.54000 |
| Target | HIV; Apoptosis |
| XLogP3-AA | 2.3 |
