Reverse Transcriptases (RTs)

Reverse transcriptases are enzymes that produce a complementary strand of DNA (cDNA) from RNA. There are currently more than 30 drugs in six major classes of anti-retroviral drugs: nucleoside retroviral inhibitors (NRTIs), non-nucleoside retroviral inhibitors (NNRTIs), protease inhibitors (PIs), integrase inhibitors (INSTIs), membrane fusion inhibitors (FIs), and CCR5 inhibitors.

Reverse transcriptases (RTs) are enzymes used to generate complementary DNA (cDNA) from RNA templates, a process called reverse transcription. RTs use an RNA template and a short primer complementary to the 3' end of the RNA to guide the synthesis of first-strand cDNA. HIV uses reverse transcriptase to convert its RNA into DNA, and blocking reverse transcriptase and reverse transcription are able to prevent HIV from replication.

CAS No.	Product Name	Inquiry
2122333-63-3	Tenofovir diphosphate triethylamine Tenofovir diphosphate triethylamine is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT).
217178-62-6	Stampidine Stampidine is a possible next-generation Pre-exposure prophylaxis (PrEP) candidate to prevent the sexual transmission of HIV-1.
2457357-99-0	FNC-TP FNC-TP is the intracellular active form of FNC which is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV.
2505-56-8	Corydine Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydin is efficient on inhibiting reverse transcriptase (RT) activity with an IC50 of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine.
27267-70-5	β-Rubromycin β-Rubromycin is a quinone antibiotic originally isolated from Streptomyces. It is effective against Gram-positive bacteria. It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 μM, respectively. β-rubromycin also inhibits HIV-1 reverse transcriptase activity.
301297-45-0	IQP-0528 IQP-0528 is a non-nucleoside reverse transcriptase inhibitor potentially for the treatment of HIV infection. IQP-0528 works by blocking virus entry and has shown antiviral activity as microbicide gels.
3056-17-5	Stavudine Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
3736-77-4	2,2'-Anhydrouridine 2,2'-Anhydrouridine (CAS# 3736-77-4) is a research tool for anticancer and antiviral studies.
379270-38-9	GS-7340 fumarate Tenofovir alafenamide fumarate, also known as Tenofovir alafenamide hemifumarate; TAF, GS-7340, is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. It is under development by Gilead Sciences for use in the treatment of HIV infection. Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (Viread), Tenofovir alafenamide has greater antiviral activity and better distribution into lymphoid tissues than that agent. Gilead has announced a phase 3 clinical trial evaluating a single-tablet regimen combining GS-7340 with cobicistat, emtricitabine and elvitegravir and plans to coformulate the drug with cobicistat, emtricitabine and the protease inhibitor darunavir. In a 48 week study comparing Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate, the results showed the prodrug to be non inferior to the established agent, but at much lower dosages and with lower incidence of adverse side effects such as impaired kidney function.
39111-07-4	Nigranoic acid Nigranoic acid is a natural product, and inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.
3952-78-1	Alizarin Complexone Alizarin-3-methyliminodiacetic acid is a colorimetric dye for the detection of fluoride ions, which is known to painters as Rose madder and Alizarin crimson. Alizarin Red is used in a biochemical assay to determine, quantitatively by colorimetry, the presence of calcific deposition by cells of an osteogenic lineage. It reacts with fluoride to form a lilac-blue complex which can be quantified colorimetrically at 620 nm to determine fluoride concentration.
552-66-9	Daidzin Daidzin is a natural organic compound in the class of phytochemicals known as isoflavones. Daidzin has shown the potential for the treatment of alcohol dependency (antidipsotropic) based on animal models. Daidzin has a significant antibacterial effect on Staphylococcus aureus and Escherichia coli. Estrogen-like effect, anti-osteoporosis, anti-estrogen activity in the treatment of menopausal syndrome, anti-hypoxic effect in the prevention and treatment of breast cancer and endometritis.
634907-30-5	Censavudine Censavudine is a nucleoside reverse transcriptase inhibitor. It is active against HIV resistant to both abacavir and tenofovir. It is a candidate for people with multi-drug resistant (MDR) strains of the virus. It is a derivative of stavudine (d4T), but is less toxic. It has demonstrated potent in vitro activity against HIV-2. It was developed by Bristol Myers-Squibb and in clinic phase 2 trials.
69655-05-6	Didanosine (DDI) Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
7481-89-2	Zalcitabine Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
87190-79-2	AzddMeC Az-Dcme is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection.
87-52-5	Gramine Gramine is a naturally occurring indole alkaloid present in several plant species. Gramine may play a defensive role in these plants, since it is toxic to many organisms. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties.
912809-27-9	Rovafovir-etalafenamide Rovafovir etalafenamide (GS-9131), a prodrug of the adenosine nucleotide analogue GS-9148, is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Rovafovir etalafenamide is potent and active against a variety of NRTI mutants, and shows potent anti-HIV-1 activity.
950913-56-1	EFdA-TP EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits HIV-1 RT with multiple mechanisms.
54-47-7	Pyridoxal-5-Phosphate A derivative of Pyridoxine. Pyridoxine is a form of vitamin B6 found commonly in food and used as dietary supplement. It can be used to treat and prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders, problems from isoniazid, and mushroom poisoning. Vitamin supplement in health care products.

※ Please kindly note that our services are for research use only.