Human immunodeficiency Virus (HIV)

all Activators (8) Antagonists (4) Inducer (1) Inhibitors (721)

CAS No.	Product Name	Inquiry
153021-75-1	Trecovirsen
15324-64-8	Glycolithocholic acid 3-sulfate
154212-56-3	Cosalane
154598-52-4	(S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Efavirenz is an NNRTI that prevents RNA plus-strand initiation with an IC50 value of 17 nM. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It has been used in combination therapy with drugs directed at the treatment of opportunistic infections such as HIV and cancer.
1550053-02-5	BRD3308 BRD3308 is a highly selective HDAC3 inhibitor with IC50 of 54 nM. BRD3308 inhibits pancreatic β-cell apoptosis induced by inflammatory cytokines or glycolipid toxic stress, and increases the release of functional insulin. BRD3308 activates HIV-1 transcription and destroys the HIV-1 incubation period.
155148-31-5	AMD 3100 octahydrochloride AMD 3100 octahydrochloride is a high selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively).
1565845-92-2	1E7-03
156879-13-9	L-739594
157810-81-6	Indinavir sulfate Indinavir is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV infection and AIDS. It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM. However, indinavir demonstrates up to a 50-fold loss in potency against the HIV-1 protease drug-resistant mutations PRL24I, PRI50V, and PRG73S (Kis = 1.4, 27, and 0.55 nM).
159096-49-8	F1839-I F1839-I is produced from Stachybotrys sp.
1591823-76-5	Ulonivirine Ulonivirine (MK-8507) is an orally active non-nucleoside reverse transcriptase inhibitor with high antiviral activity.
159736-35-3	Wikstrol A
159989-64-7	Nelfinavir An HIV-1 protease inhibitor. It inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
160707-69-7	Apricitabine Apricitabine is a highly selective and orally active HIV-1 reverse transcriptase (RT) inhibitor (Ki = 0.08 μM), with Kis of 300, 12 and 112.25 μM against DNA polymerase α, β and γ, respectively. It has been used in trials studying the treatment of HIV Infections.
1610056-01-3	Peptide T TFA It is an HIV entry inhibitor that acts by blocking chemokine-5 receptors (CCR5).
1612841-22-1	HIV-1 inhibitor-3 HIV-1 inhibitor-3 is an inhibitor of HIV infection. (Extracted from patent US2018360927)
1616968-73-0	Ritonavir-d6
161753-49-7	12-Oxocalanolide A 12-Oxocalanolide A is a chromanone derivative that is isolated from Calophyllum polyanthum. 12-Oxocalanolide A is identified as a HIV-1 reverse transcriptase (RT) inhibitor and exhibits activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors.
161814-49-9	Amprenavir Amprenavir promotes the specific interactions between the nuclear receptor pregnane X receptor (PXR) and the coactivators SRC-1 and PBP.
161897-65-0	U-89360E

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