Orthopoxvirus

Overview

A variety of compounds have been shown to be effective against orthopoxvirus infection in tissue culture. To date, ST-246 and CMX001 are the most promising compounds against orthopoxviruses. Both drugs are in intermediate-advanced stages of the drug approval process. Several drugs, such as aurintricarboxylic acid, mitoxantrone, tetrapyrroles and ditamycin, have shown antiviral activity against poxvirus in vitro. In vitro inhibitors of the lipoxygenase pathway (ETYA and BW755c) have been shown to specifically block orthopoxvirus replication. Brincidofovir is approved for the treatment of smallpox, and tecovirimat has been approved for the treatment of monkeypox. porcelain bowls. Moreover, there are a number of active compounds including interferons and interferon inducers, as well as various nucleosides or nucleotides have activity against orthopoxviruses.

A total of 14 poxviruses have been documented to infect humans, seven of which belong to the Orthopoxvirus genus, including cowpox [CPXV], monkeypox [MPXV], buffalopox, cantagalo, aracatuba, vaccinia [VACV], and variola [VARV]. Drugs for the treatment of orthopoxviruses have been developed to act by inhibiting the enzymes encoded by the smallpox virus upon infection, and the focus will be on nucleotides and nucleotides that primarily affect nucleic acid metabolism.

CAS No.	Product Name	Inquiry
185553-96-2	Thymidine-[2'-13C] As the labelled version of Thymidine, Thymidine-[2'-13C] is a constituent of deoxyribonucleic acid.
240407-53-8	Thymidine-[5'-13C] As the labelled form of Thymidine, Thymidine-[5'-13C] is a constituent of deoxyribonucleic acid.
25526-93-6	3'-Deoxy-3'-fluorothymidine(ALOVUDINE) It is an antiviral agent, DNA polymerase inhibitor and HIV inhibitor.
267243-28-7	Canertinib Canertinib is an experimental drug candidate for the treatment of cancer. It is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 = 0.8 nM), HER-2 (IC50 = 19 nM) and ErbB-4 (IC50 = 7 nM).
303-81-1	Novobiocin Novobiocin is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, thus disrupting the interaction of both p23 and Hsp70 co-chaperones with the Hsp90 complex. (IC50=700μmol/L)
38966-21-1	Aphidicolin Aphidicolin is an antibiotic produced by Cephalosporium aphidicola and Nigrospora sphaerica, which has the effect of inhibiting mitosis and anti-DNA virus. Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line.
4408-78-0	Phosphonoacetic acid Phosphonoacetic acid (CAS# 4408-78-0) is an anti-viral agent. It is also used in viral infection modifications and in superinfection exclusions from preventing cells from being infected by a second viral attack.
4754-39-6	Deoxyadenosine Deoxyadenosine is a substrate of bacterial methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase and a product inhibitor produced by radical SAM enzymes.
478511-06-7	Thymidine-[3'-13C] As the labelled version of Thymidine, Thymidine-[3'-13C] is a constituent of deoxyribonucleic acid.
478511-40-9	Telbivudine-[13C5,15N2] Telbivudine-[13C5,15N2] is a labelled compound of Telbivudine. Telbivudine is an antiviral drug used in the treatment of hepatitis B infection. It is marketed by Swiss pharmaceutical company Novartis under the trade names Sebivo (Europe) and Tyzeka (United States). Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance.
580-22-3	2-Aminoquinoline 2-Aminoquinoline (CAS# 580-22-3) is a useful research chemical.
60084-10-8	Tiazofurin Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo.
69123-98-4	Fialuridine Fialuridine (FIAU) is a thymidine-based nucleoside analog with antiviral activity. Fialuridine and its metabolites blocks DNA synthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex.
70476-82-3	Mitoxantrone dihydrochloride It is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating and antineoplastic anthraquinone derivative.
70711-41-0	Mitoxantrone-diacetate Mitoxantrone diacetate is a potent topoisomerase II inhibitor. Mitoxantrone diacetate also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone diacetate induces Apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells.
7421-40-1	Carbenoxolone disodium The sodium salt form of Carbenoxolone, which has been found to be an anti-inflammatory glucocorticoid and could inhibit 11β-hydroxysteroid dehydrogenase.
82419-36-1	Ofloxacin Ofloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic. It has antimicrobial activity. It can inhibit DNA gyrase, Topo II (topoisomerase II) and Topo IV (Topo II α).
872606-49-0	Levofloxacin-sodium Levofloxacin ((-)-Ofloxacin) sodium is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin sodium inhibits the DNA gyrase and topoisomerase IV. Levofloxacin sodium can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin sodium shows anti-orthopoxvirus activity.
93106-59-3	Enrofloxain Hydrochloride Enrofloxacin monohydrochloride is an effective antibiotic against Mycoplasma bovis with an MIC90 of 0.312 μg/mL.
289499-45-2	Canertinib dihydrochloride Canertinib dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents.

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