Endogenous Metabolite

The levels of the enormous arrays of unique small molecule metabolites are usually tightly regulated by the activities of very large enzymes and transporters responsible for the production, conversion, degradation and compartmentalization of these small molecules. Endogenous metabolites can act as functional ligands, interacting with a wide range of proteins in vivo and thus affecting the survival and proliferation of tumor cells. Therefore, many small molecule antiviral drugs directly target endogenous metabolites in vivo.

"Endogenous metabolites" are defined as the substrates or products of approximately 1900 metabolic enzymes encoded in the human genome. Metabolites are produced when a drug is metabolized into a modified form that continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.

CAS No.	Product Name	Inquiry
	Acetylcysteine-15N Acetylcysteine-15N (N-Acetylcysteine-15N) is the 15N-labeled Acetylcysteine. Acetylcysteine is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor, a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell Apoptosis. Acetylcysteine also has anti-influenza virus activities.
	Thiamine-13C3-hydrochloride Thiamine-13C3 (Thiamine chloride-13C3) hydrochloride is the 13C-labeled Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central Metabolic enzymes.
	Thiamine-d3-hydrochloride Thiamine-d3 (Thiamine chloride-d3) hydrochloride is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central Metabolic enzymes.
	Thiamine-d4-hydrochloride Thiamine-d4 (hydrochloride) is deuterium labeled Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central Metabolic enzymes.
	Thiamine-monochloride-C13-hydrochloride Thiamine monochloride-C13 hydrochloride is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central Metabolic enzymes.
	Thymidine-13C-2 Thymidine-13C-2 is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
131685-11-5	N-Acetyl-L-cysteine-[d3] N-Acetyl-L-cysteine-[d3] is a labelled metabolite of Methyl isocyanate.
132376-92-2	Thymidine-[5',5''-d2] Thymidine-[5',5''-d2] is the labelled analogue of Thymidine, which is a constituent of deoxyribonucleic acid.
185553-96-2	Thymidine-[2'-13C] As the labelled version of Thymidine, Thymidine-[2'-13C] is a constituent of deoxyribonucleic acid.
240407-53-8	Thymidine-[5'-13C] As the labelled form of Thymidine, Thymidine-[5'-13C] is a constituent of deoxyribonucleic acid.
478511-06-7	Thymidine-[3'-13C] As the labelled version of Thymidine, Thymidine-[3'-13C] is a constituent of deoxyribonucleic acid.
478511-40-9	Telbivudine-[13C5,15N2] Telbivudine-[13C5,15N2] is a labelled compound of Telbivudine. Telbivudine is an antiviral drug used in the treatment of hepatitis B infection. It is marketed by Swiss pharmaceutical company Novartis under the trade names Sebivo (Europe) and Tyzeka (United States). Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance.
71-44-3	Spermine Spermine is an endogenous polyamine derived from spermidine. Spermine acts as an inhibitor of nNOS, and an antagonist of NMDA glutamate receptor.
951-77-9	2'-Deoxycytidine A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity.
67-03-8	Thiamine hydrochloride Thiamine or vitamin B1 is a water-soluble vitamin of the B complex, its phosphate derivatives are involved in many cellular processes.
67-16-3	Thiamine Disulfide Thiamine, also called as vitamin B1, is used in combination with other B vitamins to regulate important functions of the cardiovascular system, endocrine system, and digestive system.
552-58-9	Eriodictyol Eriodictyol is a natural flavonoid found in the fruits of Citrus sinensis (L.) Osbeck. Eriodictyol exhibits activities of antidiabetic, anti-inflammatory and antioxidant. Eriodictyol can increases glucose uptake and improves insulin resistance.
616-91-1	N-Acetyl-L-cysteine N-Acetyl-L-cysteine is an antioxidant and precursor to glutathione. It has potential anticancer activity against tumor cell growth. Nutritional supplement in health care products.

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