Arenavirus

In recent years, arenaviruses have become a huge public health threat, and can cause severe hemorrhagic fever and neurological disease in humans and other animals. These viruses encode a large multi-domain RNA-dependent RNA polymerase for transcription and replication of the viral genome. With the current lack of licensed vaccines and limited therapeutic options, the development of effective anti-anavirus small molecule drugs is of high priority. Pharmacologists have identified several broadly active potent and broadly active inhibitors of arenavirus cell entry that are effective against the major hemorrhagic arenaviruses through high-throughput screening of small molecule libraries. These novel inhibitors of anavirus infection provide promising antiviral strategies by blocking the membrane fusion of anaviruses.

Hemorrhagic fever caused by anaviruses is one of the most devastating emerging human diseases. BOC Sciences provides a diversity of potent and broadly active inhibitors of arenavirus cell entry that are effective against the major hemorrhagic arenaviruses.

CAS No.	Product Name	Inquiry
	(E)-LHF-535 (E)-LHF-535 is the E-isomer of LHF-535. LHF-535 is an antiviral agent, it has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
	GP(33-41)TFA GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus
	Nucleoprotein-396-404-TFA Nucleoprotein (396-404) TFA is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) TFA is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen.
1429192-00-6	Retro-2 Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network. It has been shown to be effective against a range of bacterial and virus pathogens, both in vitro and in animal models.
1450929-77-7	LHF-535 LHF-535 is an antiviral agent that targets the arenavirus envelope glycoprotein, suggesting its potential use for the treatment of Lassa fever and other fevers caused by arenavirus.
158475-79-7	Nucleoprotein 396-404 Nucleoprotein (396-404) is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV).
160543-97-5	Glycoprotein 276-286 Glycoprotein (276-286) is a Db-restricted peptide derived from lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP) and corresponds to amino acids 276-286.
161928-86-5	GP (33-41) GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus.
2320274-72-2	ST-193-hydrochloride ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
297730-17-7	AVN-944 AVN-944 (VX-944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only.
31721-94-5	5,7-Dihydroxychromone 5,7-Dihydroxychromone(DHC) is a natural flavonoid found in the bark of Garcinia cambogia. 5,7-Dihydroxychromone can regulate blood glucose levels and it can inhibit the radial growth of cultures of the soil pathogenic fungi Rhizoctonia solani and Scleroti
489416-12-8	ST-193 ST-193 is a potent, broad-spectrum small-molecule inhibitor of arenavirus entry and exhibits submicromolar antiviral activity in vitro. ST-193 inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
4643-58-7	Verrucarin J Verrucarin J is produced by the strain of Myrothecium verrucaria NRRL 3003. The ED50 of Verrucarin J on giant cell tumor P-815 cells was about 0.001 μg/mL.

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