Antiviral Drug Formulation Technology
A scalable formulation process ensures the stability of antiviral drug compounds to pass through clinical trials to commercial launch. Advanced formulation technology is useful to facilitate the delivery of a therapeutic compound, which is useful to optimize the absorption or distribution of therapeutic compounds in the body.
BOC Sciences has introduced advanced technologies and facilities to efficiently achieve bioavailability of your antiviral drug, and our formulation development team is led by industry veterans to develop different solutions for a wide range of antiviral drug molecules. We are able to address multiple challenges from solubility issues, excipient incompatibility, carrier stability to controlled release. Moreover, our team can use expertise in medicinal chemistry to guide you to the optimal formulation for scale-up.
Available Technologies
We ensure that pharmaceutical formulations of each antiviral drug are prepared and analyzed appropriately by following a standard formulation procedure. Our comprehensive Antiviral Drug Formulation Technology include:
- Spray dried dispersion
Spray dried dispersion is a widely-applied technique used to enhance the bioavailability of poorly water soluble antiviral drug compounds. Drug product intermediates based on spray dried dispersion technology can be formulated into capsules, tablets and other solid dosage forms. At BOC Sciences, our experienced cross-functional team is able to provide reliable spray dried services for antiviral APIs and drug products, providing a rapid and cost-effective approach to the development of your antiviral drug from preclinical to commercialization.
Figure 1. Nano spray drying as a method for drying and formulation. (Hagag Y.; et al. 2015)
- Hot melt extrusion
Hot melt extrusion technology offers a processing option for product development of oral dissolvables that maximizes API-polymer mixing while reducing API degradation. Our hot melt extrusion services enable optimal drug delivery of stable and effective antiviral drug dosage forms. In addition, our manufacturing facilities support both research-scale and large scale production of antiviral drugs, ensuring process scale-up as your molecule progresses through various clinical stages.
- Nano suspension
The low solubility of drugs in aqueous media leads to poor bioavailability and is not suitable for amorphous solid dispersions. Early stage studies of small molecule drugs have shown that nano-milling of insoluble compounds can significantly improve human PK profiles. BOC Sciences' formulation team has extensive experience in screening nanoformulations for PK, toxicology and clinical studies, and we are able to provide high quality grinding and drying services for nano formulations.
Figure 2. Schematic representation of formation of a PASD through hot melt extrusion and spray drying processes. (Surikutchi, B. T.; et al. 2013)
- Pediatric formulations
We offer a variety of flexible antiviral dosage form options to meet the specific needs of pediatric dosing, such as taste masking and differences in the ease, frequency and safety of dosing regimens.
Our pediatric antiviral drug formulations include:
- Oral solution suspensions
- Taste masking
- Mini-tablets
- Pellets
- Extended release coating
- Oral dosage technology
- Dry blend
- Roller compaction
- Wet granulation
- Compression
- Film coating
- Pelletization
Figure 3. Typical dissolution mechanism and factors to explore when developing IR solid oral dosage forms. (Hermans, A.; et al. 2017)
Supported Formulation Development
- Oral formulations
- Solutions, suspensions
- Tablets: immediate-release/controlled-release tablets, orally disintegrating tablets, chewable tablets, effervescent tablets, bilayer tablets, mini tablets
- Capsules: liquid, powder, granules and/or tablets in hard capsules or HPMC capsules
- Particulate: single or multiple types of particle combinations
- Bottles or capsules
- Powder in sachets
- Enteral drug delivery
- Injectable formulations
- Solution
- Suspension
- Microemulsion
- Nanocrystal
- Complexes
- Microsphere
- Lyophilized powder
- In situ gel
- Formulations for other routes of drug delivery
- Creams, ointments
- Ophthalmic dosage form
- Transdermal patch
Why Partner with BOC Sciences?
- We apply our years of proven expertise and experience in antiviral drug development to improve the success of your program
- Our continuously updated facilities support a range of antiviral drug analysis and manufacturing services
- BOC Sciences' experienced team of scientists and regulatory staffs are focused on working with our clients to deliver timely and high-quality small molecule antiviral drugs
- Our partnerships with leading experts in emerging technologies allow us to apply innovative solutions to your antiviral drug research programs
References
- Hagag Y.; et al. Evaluation of nano spray drying as a method for drying and formulation of therapeutic peptides and proteins. Frontiers in Pharmacology. 2015.
- Surikutchi, B. T.; et al. Drug-excipient behavior in polymeric amorphous solid dispersions. Journal of Excipients and Food Chemicals. 2013. 4(3): 70-94.
- Hermans, A.; et al. Approaches for Establishing Clinically Relevant Dissolution Specifications for Immediate Release Solid Oral Dosage Forms. Journal of the American Association of Pharmaceutical Scientists. 2017. 19: 1537-1549.
※ Please kindly note that our services are for research use only.
