HIF/HIF Prolyl-Hydroxylase

Deletion of PHD enzymes leads to stabilization of HIFs and offers potential therapeutic options for many ischemic diseases such as peripheral artery occlusive disease, myocardial infarction and stroke. Thus, the regulation of HIF-1α-mediated cardioprotection by PHD has led to a great deal of interest in these molecules as potential therapeutic targets for cardiovascular and ischemic diseases. This mechanism of inhibition may lead to a clinically useful strategy to protect the myocardium from ischemia and reperfusion injury. Recently, a PHD inhibitor has been reported to modulate HIF-1α signaling and protect the failing heart after myocardial infarction. In addition, PHD1 deficiency has been found to have beneficial effects by reprogramming basal metabolism to increase skeletal muscle tolerance to hypoxia.

Prolyl hydroxylases belong to a family of iron- and 2-oxoglutamate-dependent dioxygenases. Hypoxia-inducible factor (HIF) prolyl hydroxylases are known as prolyl hydroxylase domain (PHD) enzymes and play an important role in the oxygen regulation of physiological networks. In recent years, PHDs are attracting increasing interest as potential therapeutic targets for a wide range of diseases, and small molecule drugs capable of recognizing PHDs.

CAS No.	Product Name	Inquiry
27591-97-5	Tilorone Tilorone is a member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is a synthetic, small molecular weight compound that is an orally active interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist, used as an antiviral drug. Its hydrochloride salt is used as an antiviral drug. It has a role as an antiviral agent, an antineoplastic agent, and an anti-inflammatory agent.
27591-69-1	Tilorone dihydrochloride Tilorone dihydrochloride, as a broad-spectrum, orally active antiviral agent, is an orally active interferon inducer.
327-97-9	Chlorogenic acid Chlorogenic acid is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds. Chlorogenic acid exhibits an anti-inflammatory effect, and reduce blood pressure. Chlorogenic acid has a wide range of biological activities. Modern scientific research on the biological activity of chlorogenic acid has penetrated into many fields such as food, health care, medicine and daily chemical industry.

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HIF/HIF Prolyl-Hydroxylase

Tilorone

Tilorone dihydrochloride

Chlorogenic acid