Virus Protease

CAS No.	Product Name	Inquiry
	4-Hydroxy-2-methylbenzenesulfonic-acid-ammonium 4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity of Policresulen. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells and is a potent NS2B/NS3 protease inhibitor with an IC50 of 0.48 μg/mL. Policresulen can slightly affect the protease stability.
	5-Hydroxytoluene-2-4-disulphonic-acid-diammonium 5-Hydroxytoluene-2,4-disulphonic acid diammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC50 of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC50 of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability.
	CYP2C9-CYP2C19-IN-1 CYP2C1/CYP2C19-IN-2 (compound 21d) is a potent CYP2C9/CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C1/CYP2C19-IN-2 can be used in study of anti-ZIKV
	Dabcyl-KTSAVLQSGFRKM-Glu-Edans-NH2 Dabcyl-KTSAVLQSGFRKM-Glu(Edans)-NH2 is a fluorogenic peptide, as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKM-Glu(Edans)-NH2 can be used for researching 2019-nCoV (COVID-19) infection.
	Encephalitic-alphavirus-IN-1 Encephalitic alphavirus-IN-1 has antiviral activity for VEEV and EEEV with EC50s of 0.24 μM and 0.16 μM, respectively.
	NS2B-NS3-IN-2 NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC50 of 6.0 nM and Ki of 0.66 µM.
	NS2B-NS3-IN-3 NS2B/NS3-IN-3 (Compd 66) is an inhibitor of Flavivirus NS2B-NS3 protease.
	NS2B-NS3-IN-4 NS2B/NS3-IN-4 (Compound 34e) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 0.69 µM and 1.04 µM against DENV2 and ZIKV NS2B/NS3 proteases, respectively.
	NS2B-NS3-IN-5 NS2B/NS3-IN-5 (Compound 25b) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 0.67 µM and 4.38 µM against ZIKV and DENV2 NS2B/NS3 proteases, respectively.
	NS2B-NS3-IN-7 NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a Ki value of 2.33 nM.
	Probucol-d6 Probucol-d6 is deuterium labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
	Rupintrivir-d4 Rupintrivir-d4 (AG7088-d4) is the deuterium labeled Rupintrivir. Rupintrivirvr (AG7088), an antiviral drug, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.
	SP-471 SP-471 is a potent dengue virus (DENV) protease inhibitor with IC50 value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV.
	SP-471P SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.
	SP-inhibitor-1 SP inhibitor 1 (compound 34) is a selective SARS-CoV-2 spike protein (SP) inhibitor with an IC50 of 3.26 μM, >25 μM, >25 μM for SP, Mpro and PLpro protein, respectively. SP inhibitor 1 is a vitro SARS-CoV-2 replication inhibitor at non-toxic concentrations (0.3250<5.98 μM). SP inhibitor 1 shows cellular antiviral activity.
	ZIKV-IN-4 ZIKV-IN-4 (compound 5b) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=3.49 μM). ZIKV-IN-4 effectively inhibits the activity of ZIKV NS5 MTase.
	ZIKV-IN-5 ZIKV-IN-5 (compound 5c) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=0.71 μM). ZIKV-IN-5 effectively inhibits the activity of ZIKV NS5 MTase.
101418-00-2	Policresulen Policresulen is often used for gynecological infections. It is also used as a topical antiseptic agent and hemostatic agent, local.
1159908-45-8	Palmitoyl Ethanolamide-[7,7,8,8-d4] Palmitoyl Ethanolamide-[7,7,8,8-d4] is the labelled analogue of Palmitoylethanolamide, which is an endogenous CB2 cannabinoid receptor agonist and a selective GPR55 agonist.
1173019-29-8	Probucol-(propyl-[13C3]) Probucol-(propyl-[13C3]) is a labelled analogue of Probucol which can enhance selective uptake of HDL-associated cholesteryl esters.

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