Virus Protease

CAS No.	Product Name	Inquiry
	Probucol-d6 Probucol-d6 is deuterium labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
	PROTAC SARS-CoV-2 Mpro degrader-2
	PROTAC SARS-CoV-2 Mpro degrader-3
	RA-0002034
	Rupintrivir-d4 Rupintrivir-d4 (AG7088-d4) is the deuterium labeled Rupintrivir. Rupintrivirvr (AG7088), an antiviral drug, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.
	Rupintrivir-d7
	SARS-CoV-2 3CLpro-IN-21
	SARS-CoV-2 Mpro-IN-23
	SARS-CoV-2 Mpro-IN-4
	SARS-CoV-2 Mpro-IN-7
	SARS-CoV-2/MERS Mpro-IN-1
	SARS-CoV-2/MERS Mpro-IN-2
	SARS-CoV-2-IN-27
	SARS-CoV-2-IN-36
	SARS-CoV-2-IN-49
	SARS-CoV-2-IN-58
	SARS-CoV-2-IN-94
	SP-471 SP-471 is a potent dengue virus (DENV) protease inhibitor with IC50 value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV.
	SP-471P SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.
	SP-inhibitor-1 SP inhibitor 1 (compound 34) is a selective SARS-CoV-2 spike protein (SP) inhibitor with an IC50 of 3.26 μM, >25 μM, >25 μM for SP, Mpro and PLpro protein, respectively. SP inhibitor 1 is a vitro SARS-CoV-2 replication inhibitor at non-toxic concentrations (0.3250<5.98 μM). SP inhibitor 1 shows cellular antiviral activity.

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