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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
SP-471
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| Category | Virus Protease |
| Description | SP-471 is a potent dengue virus (DENV) protease inhibitor with IC50 value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV. |
Product Information
| Synonyms | SP-471|CHEMBL4879251|HY-144646|CS-0433381 |
| Molecular Weight | 572.5 |
| Molecular Formula | C33H26BrN5 |
| Canonical SMILES | C1=CC(=CC(=C1)Br)CN2C3=C(C=C(C=C3)C4=CC(=CC=C4)C(=N)N)C5=C2C=CC(=C5)C6=CC(=CC=C6)C(=N)N |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 820 |
| Exact Mass | 571.13716 |
| In Vitro | SP-471 (10 μM; 48 hours) exhibits an EC50 value of 48.13 μM and CC50 over 100 μM for ADE infection in human PBMCs. |
| Target | IC50: 18 μM (DENV) |
| XLogP3-AA | 6.8 |
