Virus Protease

CAS No.	Product Name	Inquiry
2222042-47-7	As-358 As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM.
223537-30-2	Rupintrivir Rupintrivir is a potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). It has been demonstrated to have in vitro activity against all HRVs tested, consistent with its interaction with a strictly conserved subset of amino acids in the 3C protease. It blocks processing of viral proteins, thus blocking viral replication.
2316-26-9	3,4-Dimethoxycinnamic acid, predominantly trans 3,4-Dimethoxycinnamic acid isolated from the leaves of Phyllostachys heterocycla.
23288-49-5	Probucol Enhances selective uptake of HDL-associated cholesteryl esters.
2330878-43-6	L-Lysine-d3 hydrochloride
2374723-26-7	As-358-hydrochloride As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety.
2407227-31-8	NITD-688 NITD-688 is an orally active panserotype inhibitor of dengue virus NS4B protein that can be used in dengue virus (DENV) studies.
2412965-59-2	SARS-CoV-2-IN-1
2459657-57-7	NS2B-NS3-IN-6 NS2B/NS3-IN-6 (Compound 1a) is an allosteric DENV and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 2.23 µM and 25.2 µM against ZIKV and DENV proteases, respectively.
263707-16-0	ESI-09 ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.ESI-09 is a novel noncyclic nucleotide EPAC antagonist that is capable of specifically blocking intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic β cells. EPAC1 plays an important role in pancreatic cancer cell migration and invasion, and thus represents a potential target for developing novel therapeutic strategies for pancreatic cancer.
2705402-91-9	N-Desmethylclozapine-d8 hydrochloride
2708343-64-8	L-Lysine-d9 hydrochloride
2708934-53-4	CCF0058981 CCF0058981, a non-covalent SARS-CoV-2 3CLpro (SC2) inhibitor (IC50 = 68 nM), can inhibit SARS-CoV-1 3CLpro (SC1) with an IC50 of 19 nM. It has antiviral efficacy and has the potential to study COVID-19.
2742982-16-5	4-Hydroxy-2-methylbenzenesulfonic acid ammonium
2762166-06-1	ZIKV-IN-1 ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 µM and EC90 of 6.8 µM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain.
2766185-81-1	SP inhibitor 1
2817810-96-9	SARS-CoV-2-IN-95
2832876-90-9	NS2B/NS3-IN-3
2832876-91-0	NS2B/NS3-IN-3 hydrochloride
284664-96-6	L-Lysine-d4 hydrochloride L-Lysine-[4,4,5,5-d4] hydrochloride is a labelled L-Lysine hydrochloride. Lysine is an essential amino acid obtained from red meats and fish. Lysine inhibits HSV growth via knocking out arginine.

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