Rupintrivir-d4

Category	Enterovirus (EV)
Description	Rupintrivir-d4 (AG7088-d4) is the deuterium labeled Rupintrivir. Rupintrivirvr (AG7088), an antiviral drug, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.

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Synonyms	Rupintrivir-d4\|HY-106161S\|CS-0202594
Molecular Weight	602.69
Molecular Formula	C31H39FN4O7
Canonical SMILES	CCOC(=O)C=CC(CC1CCNC1=O)NC(=O)C(CC2=CC=C(C=C2)F)CC(=O)C(C(C)C)NC(=O)C3=NOC(=C3)C
Boiling Point	866.7°C at 760mmHg
Flash Point	477.9°C
Purity	≥98% (HPLC)
Density	1.213g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	1010
Exact Mass	602.30538474
Index Of Refraction	1.537
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs.
PSA	156.70000
Target	Virus Protease; Enterovirus
Vapor Pressure	1.87E-30mmHg at 25°C
XLogP3-AA	3.1