4E2RCat

Category	Virus Protease
CAS	432499-63-3
Description	4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.

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Product Information

Synonyms	4E2RCat\|432499-63-3\|5-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-chlorobenzoic acid\|MFCD03706106\|NB-217\|ZINC33313682\|AT14170\|CS-6204\|NCGC00686697-01\|BS-51906\|HY-100733\|5-[5-[(Z)-(3-benzyl-4-oxo-2-thioxo-thiazolidin-5-ylidene)methyl]-2-furyl]-2-chloro-benzoic acid\|Benzoic acid, 2-chloro-5-[5-[(Z)-[3-phenylmethyl-4-oxo-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-
Molecular Weight	455.93
Molecular Formula	C22H14ClNO4S2
Canonical SMILES	C1=CC=C(C=C1)CN2C(=O)C(=CC3=CC=C(O3)C4=CC(=C(C=C4)Cl)C(=O)O)SC2=S
Boiling Point	659.0±65.0 °C at 760 mmHg
Flash Point	352.3±34.3 °C
Purity	>98%
Density	1.6±0.1 g/cm3
Solubility	In Vitro: DMSO : 23.33 mg/mL(51.17 mM;Need ultrasonic) In Vivo: 1. Add each solvent one by one:10% DMSO >> 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.33 mg/mL (5.11mM); Clear solution
Appearance	Light yellow to yellow (Solid)
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	724
Exact Mass	455.005280
Index Of Refraction	1.760
In Vitro	4E2RCat prevents the interaction between eIF4E and eIF4G, inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. In addition, it inhibits coronavirus replication in a dose- and time-dependent manner.
In Vivo	4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death.
Target	Eukaryotic Initiation Factor (eIF); Autophagy; Virus Protease
Vapor Pressure	0.0±2.1 mmHg at 25°C
XLogP3-AA	5.4