AX20017

Category	Virus Protease
CAS	329221-38-7
Description	AX20017 is a highly selective PknG inhibitor. It acts by blocking the proliferation of M. tuberculosis. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10μM or higher) that does not otherwise affect the growth of BCG outside its infected host.

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Synonyms	AX 20017; AX-20017; PknG Inhibitor; 2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
IUPAC Name	2-(cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
Molecular Weight	264.35
Molecular Formula	C13H16N2O2S
Canonical SMILES	C1CCC2=C(C1)C(=C(S2)NC(=O)C3CC3)C(=O)N
InChI	InChI=1S/C13H16N2O2S/c14-11(16)10-8-3-1-2-4-9(8)18-13(10)15-12(17)7-5-6-7/h7H,1-6H2,(H2,14,16)(H,15,17)
InChIKey	VATFNEMGBRWLHI-UHFFFAOYSA-N
Boiling Point	465.32°C at 760 mmHg
Melting Point	213.11°C
Purity	≥98% (HPLC)
Density	1.42 g/cm3
Solubility	Soluble in DMSO (5 mg/ml)
Appearance	Solid powder
Storage	3 years-20°Cpowder 2 years-80°Cin solvent
Complexity	370
Exact Mass	264.09324893
Target	Virus Protease
XLogP3-AA	2.2