Lycorine

Category	Virus Protease
CAS	476-28-8
Description	Source from bulbus of Lycoris radiata (L. Herit.) Herb. Anti-cancer effects of Lycorine were dependent on STAT expression. We suggest that Lycorine is a potential therapeutic in prostate cancer. Inhibition of HDAC activity is responsible for at least part of the induction of cell-cycle arrest in the G0/G1 phase by Lycorine and provide a mechanistic framework for further exploring the use of Lycorine as a novel antitumor agent.

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Synonyms	lycorine;476-28-8;Amarylline;Galanthidine;Narcissine;Licorine;(-)-Lycorine;NSC401360;NSC683873;CHEBI:6601;CHEMBL400092;I9Q105R5BU;GNF-PF-4974;NSC 401360;Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-;NSC-401360;NSC-683873;(1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol;9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alpha,2beta-diol;Galanthan-1,2-diol, 3,12-didehydro-9,10-(methylenebis(oxy))-, (1-alpha,2-beta)-;(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol;(1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol;MFCD00243111;EINECS 207-503-6;UNII-I9Q105R5BU;3,3a-Didehydrolycoran-1alpha,2beta-diol;Likorin;(1S,2S,12BS,12CS)-2,4,5,7,12B,12C-HEXAHYDRO-1H-(1,3)DIOXOLO(4,5-J)PYRROLO(3,2,1-DE)PHENANTHRIDINE-1,2-DIOL;3,2.beta.-diol;Lycoran-1.alpha.,2.beta.-diol, 3,3a-didehydro-;LYCORINE [MI];Lycoran-1alpha,2beta-diol, 3,3a-didehydro-;BSPBio_001302;KBioGR_000022;KBioSS_000022;SCHEMBL626071;BCBcMAP01_000100;KBio2_000022;KBio2_002590;KBio2_005158;KBio3_000043;KBio3_000044;DTXSID60197208;XGVJWXAYKUHDOO-DANNLKNASA-N;Bio2_000022;Bio2_000502;HMS1361B04;HMS1791B04;HMS1989B04;HMS3402B04;HMS3885I12;HY-N0288;BDBM50221066;MFCD00221746;NSC781764;s3903;Lycoran-1.alpha., 3,3a-didehydro-;AKOS000278045;CCG-208232;NSC-781764;IDI1_033772;QTL1_000052;SMP1_000184;NCGC00163413-01;NCGC00163413-02;NCGC00163413-03;NCGC00163413-07;1ST40280;MS-24104;NCI60_003767;LycorineGalanthidine; Narcissine; Licorine;CS-0008781;NS00031710;C08532;Q420314;BRD-K64909280-001-02-7;3,12-[methylenebis(oxy)]-galanthan-1.alpha.,2.beta.-diol;Galanthan-1, 3,12-didehydro-9,10-[methylenebis(oxy)]-, (1.alpha.,2.beta.)-;Galanthan-1, 3,4-didehydro-11,12-[methylenebis(oxy)]-, (1.alpha.,2.beta.)-;(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.0?,??.0?,?.0??,??]nonadeca-2,4(8),9,15-tetraene-17,18-diol;1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, (1S,2S,12bS,12cS)-;2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, (1S,2S,12bS, 12cS)-;2,5,7,12b,12c-Hexahydro-1H-[1,3]-dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol;3KD;
IUPAC Name	(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol
Molecular Weight	287.31
Molecular Formula	C16H17NO4
Canonical SMILES	O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4
InChI	InChI=1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2/t11-,14-,15+,16+/m0/s1
InChIKey	XGVJWXAYKUHDOO-DANNLKNASA-N
Purity	>98%
Density	1.53 g/cm3
Appearance	Solid
Application	Antiviral, anticancer