Palmatine

Category	Virus Protease
CAS	3486-67-7
Description	Palmatine could potentially be developed for the treatment of flavivirus infections.Palmatine is an inhibitor of dopamine generation.

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Product Information

Synonyms	7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-berbiniu; 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium; berbericinine; g)quinolizinium,5,6-dihydro-2,3,9,10-tetramethoxy-dibenzo(; o,o-dimethyldemethyleneberberine; palmatin; PALMATINE; 2,3,9,10-TETRAMETHOXY-5,6-DIHYDRO-ISOQUINO[3,2-A]ISOQUINOLINYLIUM
Molecular Weight	352.4
Molecular Formula	C21H22NO4
Canonical SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC
Melting Point	205 °C
Purity	>98%
Solubility	Soluble in DMSO
Appearance	Yellow Powder
Application	anti-inflammatory
Storage	Store at -20°C
Complexity	475
Exact Mass	352.15488318
In Vitro	Palmatine (0-100 μM; 42 h) suppresses WNV with an EC50 value of 3.6 μM, and reduce the viral titers of DENV-2 and YFV with EC50 values of 26.4 μM and 7.3 μM, respectively. Palmatine (0-1128 μM; 24-72 h) inhibits colon cancer cell proliferation. Palmatine (0-704 μM; 24 h) reduces AURKA protein levels, induces G2/M phase arrest, and induces Apoptosis in colon cancer cells via the mitochondrial associated pathway.
In Vivo	Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells. Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056)-induced fulminant hepatic failure in mice. Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice. Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice.
PSA	40.80000
Target	Indoleamine 2,3-Dioxygenase (IDO); Virus Protease; Aurora kinase; Apoptosis
XLogP3-AA	3.7