Herpes simplex Virus (HSV)

CAS No.	Product Name	Inquiry
	Trigonelline-d3-chloride Trigonelline-d3 chloride (Trigonelline-d3 hydrochloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.
	Z-L(D-Val)G-CHN2
5116-24-5	5-Hydroxymethyl-2'-deoxyuridine 5-(Hydroxymethyl)-2'-deoxyuridine is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM). 5-(Hydroxymethyl)-2'-deoxyuridine acts synergistically with 5-fluorouracil (5-FU) against HT-29, HCT116, PANC-1, and EKVX cancer cells with no effect on WI38 embryonic lung fibroblasts.
273388-09-3	WAY-150138 WAY 150138, belonging to a novel group of thiourea compounds, can cause the inhibition of the herpes simplex virus.
348086-71-5	BAY-57-1293 BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. Potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections with IC50 value of 20 nM for inhibition of the replication of both HSV-1 and HSV-2 in Vero cells, and ED50 value of 0.5 mg/kg for both HSV-1 and HSV-2 in the murine lethal challenge model of disseminated herpes.
69123-90-6	Fiacitabine Fiacitabine is a selective inhibitior of DNA replication of herpes simplex virus(HSV). It was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloquanosine and slightly more toxic to normal cells.
59277-89-3	Acyclovir Aciclovir is a synthetic nucleoside analogue active against herpesviruses. It is primarily used for the treatment of herpes simplex virus infections, chickenpox and shingles.
1222800-79-4	ML324 ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes.
29700-22-9	Oxyresveratrol Oxyresveratrol is isolated from the herbs of Dracaena angustifolia. Because toxicity to glia could be beneficial by inhibiting reactive gliosis, Oxyresveratro is useful to trauma models. Oxyresveratrol can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2.
61276-17-3	Acteoside Verbascoside is a bioactive polyphenol from olive oil mill wastewater with known antioxidant activity, which is a protein kinase C inhibitor.
1180-35-4	Epipodophyllotoxin acetate Acetylepipodophyllotoxin isolated from the root of Dysosma versipellis (Hance) M.Cheng ex Ying.
480-37-5	Pinostrobin Pinostrobin, which can be extracted from the herbs of Cajanus cajan, may be responsible for the anti-hemorrhagic and analgesic activity (peripheral analgesic activity) of Renealmia alpinia. It leads to depolarisation of the cell potential of endothelial cells. Pinostrobin was able to exert a neuroprotective effect against Aβ(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis. Besides, Pinostrobin (50mg/kg/dose) possesses definite therapeutical effect in the development of lesion score.
514-62-5	Ferruginol Ferruginol is isolated from the herbs of Salvia yunnanensis.
104196-68-1	Manzamine A Manzamine A is an alkaloid in the class of β-carboline isolated from the marine sponges. It acts as an inhibitor of glycogen synthase kinase 3β (GSK3β). It exhibits inhibitory effects against growth of the rodent malaria parasite Plasmodium berghei in vivo.
25775-90-0	cis-Capsaicin Zucapsaicin, also referred to cis-Capsaicin, is a prototype vanilloid receptor agonist used to treat osteoarthritis of the knee and other neuropathic pain.
99011-02-6	Imiquimod An agonist of TLR7 with immune response modifying activity, Approved for basal cell carcinoma, In Phase III for VIN and CIN, Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells.
35899-54-8	5'-Deoxy-5'-isobutylthioadenosine 5'-Deoxy-5'-isobutylthioadenosine selectively inhibits spermine synthase.
124832-27-5	L-Valacyclovir Hydrochloride Valaciclovir HCl is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B.
841301-32-4	Amenamevir Amenamevir is a DNA helicase-primase inhibitor. It has anti-HSV activity against herpes simplex keratitis. In Mar 2016, Mahuro completed a phase III trial in Herpes simplex virus infections in Japan.
20350-15-6	Brefeldin A Brefeldin is an antibiotic produced by Penicillum brefeldianum S-464, Pen. cyaneum S-ll, Pen. decumbens, Pen. simplicissimum S-543, etc. Brefeldin A has anti-candida, aspergillus and anti-tumor activity.

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