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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
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- HCV Protease
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- HIV Protease
- Human immunodeficiency Virus (HIV)
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- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
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- West Nile virus
- Antiviral intermediates
Brefeldin A
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| Category | Herpes simplex Virus (HSV) |
| CAS | 20350-15-6 |
| Description | Brefeldin is an antibiotic produced by Penicillum brefeldianum S-464, Pen. cyaneum S-ll, Pen. decumbens, Pen. simplicissimum S-543, etc. Brefeldin A has anti-candida, aspergillus and anti-tumor activity. |
Product Information
| Synonyms | Ascotoxin; Synergisidin; Decumbin; Nectrolide |
| IUPAC Name | (1R,2R,3E,7S,11E,13S,15S)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one |
| Molecular Weight | 280.36 |
| Molecular Formula | C16H24O4 |
| Canonical SMILES | CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O |
| InChI | InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1 |
| InChIKey | KQNZDYYTLMIZCT-KQPMLPITSA-N |
| Boiling Point | 492.7°C at 760 mmHg |
| Melting Point | 204-205°C |
| Flash Point | 180.8±22.2 °C |
| Purity | >98% |
| Density | 1.108 g/cm3 |
| Solubility | Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility. |
| Appearance | Colorless Crystal |
| Application | Antiviral Agents |
| Storage | -20°C |
| Complexity | 388 |
| Exact Mass | 280.16745924 |
| Index Of Refraction | 1.513 |
| In Vitro | Brefeld A treatment for 15 or 40 h causes significant swelling of the endoplasmic reticulum (ER) and transfers its localization to the periphery of normal rat kidney (NRK) cells. Prolonged Brefeldin A therapy leads to significant destruction of the MT and actin cytoskeleton. Brefeldin A induces adherence-free cell death in MDA-MB-231 breast cancer cells, inhibits the formation of the MDA-MB-231 colony in 3D and 2D cultures, and inhibits the migration of MDA-MB and MMP 9 (Matrix Metallopeptidase 9) activity-231. |
| PSA | 66.76000 |
| Target | Autophagy; CRISPR/Cas9; Mitophagy; HSV; Antibiotic |
| Vapor Pressure | 0.0±2.8 mmHg at 25°C |
| XLogP3-AA | 2 |
