Manzamine A

Category	Herpes simplex Virus (HSV)
CAS	104196-68-1
Description	Manzamine A is an alkaloid in the class of β-carboline isolated from the marine sponges. It acts as an inhibitor of glycogen synthase kinase 3β (GSK3β). It exhibits inhibitory effects against growth of the rodent malaria parasite Plasmodium berghei in vivo.

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Synonyms	Manzamine A;104196-68-1;CHEMBL403233;Keramamine A;CHEBI:66667;(4aR,7S,7aR,13Z,14aR,15aR,18Z)-5-(9H-beta-carbolin-1-yl)-4,4a,9,10,11,12,14a,15-octahydro-3H-7,2-oct[3]enoazocino[1',2':1,5]pyrrolo[2,3-i]isoquinolin-7(1H,7aH)-ol;MANZAMINE;CHEMBL326531;SCHEMBL14377624;DTXSID001098329;BDBM50232478;AKOS040748872;HY-117025;CS-0063523;Q27135285;(1R,2R,4R,5Z,12R,13S,16Z)-25-(9H-pyrido[3,4-b]indol-1-yl)-11,22-diazapentacyclo[11.11.2.12,22.02,12.04,11]heptacosa-5,16,25-trien-13-ol;(1R,4S,9Z,13S,13aR,20aR,21aR)-2,3,5,6,7,8,11,12,15,16,17,18,20a,21-Tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-1,13-etheno-4,21a-methano-1H-azocino[1a(2),2a(2):1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol;
IUPAC Name	(1R,2R,4R,5Z,12R,13S,16Z)-25-(9H-pyrido[3,4-b]indol-1-yl)-11,22-diazapentacyclo[11.11.2.12,22.02,12.04,11]heptacosa-5,16,25-trien-13-ol
Molecular Weight	548.76
Molecular Formula	C36H44N4O
Canonical SMILES	O[C@]1(CC/C=C\CCCC2)[C@@]3([H])[C@@](C[C@@]4([H])N3CCCC/C=C\4)(C[N@@]2CC5)[C@]5([H])C(C6=C(NC7=CC=CC=C87)C8=CC=N6)=C1
InChI	InChI=1S/C36H44N4O/c41-36-18-10-4-1-2-5-11-20-39-22-17-30(35(25-39)23-26-13-7-3-6-12-21-40(26)34(35)36)29(24-36)32-33-28(16-19-37-32)27-14-8-9-15-31(27)38-33/h1,4,7-9,13-16,19,24,26,30,34,38,41H,2-3,5-6,10-12,17-18,20-23,25H2/b4-1-,13-7-/t26-,30-,34+,35-,36-/m0/s1
InChIKey	FUCSLKWLLSEMDQ-MKYGIPPKSA-N
Purity	≥98%
Appearance	Solid Powder
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.