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Antiviral API
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cis-Capsaicin
![{PARAM:[Name]}()](https://resource.bocsci.com/structure/25775-90-0.gif)
| Category | Herpes simplex Virus (HSV) |
| CAS | 25775-90-0 |
| Description | Zucapsaicin, also referred to cis-Capsaicin, is a prototype vanilloid receptor agonist used to treat osteoarthritis of the knee and other neuropathic pain. |
Product Information
| Synonyms | (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide; BRN 4261852; cis-Capsaicin; Civamide; Zucapsaicin, trade name Civanex |
| IUPAC Name | (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide |
| Molecular Weight | 305.42 |
| Molecular Formula | C18H27NO3 |
| Canonical SMILES | CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC |
| InChI | InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6- |
| InChIKey | YKPUWZUDDOIDPM-VURMDHGXSA-N |
| Boiling Point | 85-86°C0.003 mm Hg(lit.),378°C at 760 mmHg |
| Melting Point | 71.5-74.5 |
| Flash Point | 107.1°C |
| Purity | 98% |
| Density | 0.89 g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Application | Capsaicin analogue (C175680). It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic. |
| Storage | 4°C, protect from light * In solvent : -80°C, 6 months -20°C, 1 month (protect from light) |
| Complexity | 341 |
| Exact Mass | 305.19909372 |
| Index Of Refraction | 1.463 |
| In Vitro | (Z)-Capsaicin is the cis isomer of capsaicin, acting as a TRPV1 agonist. (Z)-Capsaicin may also blocks the neruonal calcium channel. |
| In Vivo | (Z)-Capsaicin (Zucapsaicin) significantly attenuates nociceptive behavior after oral administration in rats. (Z)-Capsaicin is also tolerated in the primary or recurrent experimental genital herpes simplex virus infection in guinea pigs. |
| PSA | 26.30000 |
| Target | TRPV1 receptor |
| XLogP3-AA | 3.6 |
