Oxyresveratrol

Category	Herpes simplex Virus (HSV)
CAS	29700-22-9
Description	Oxyresveratrol is isolated from the herbs of Dracaena angustifolia. Because toxicity to glia could be beneficial by inhibiting reactive gliosis, Oxyresveratro is useful to trauma models. Oxyresveratrol can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2.

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Product Information

Synonyms	Hydroxyresveratrol; Tetrahydroxystilbene
IUPAC Name	4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol
Molecular Weight	244.2
Molecular Formula	C14H12O4
Canonical SMILES	C1=CC(=C(C=C1O)O)C=CC2=CC(=CC(=C2)O)O
InChI	InChI=1S/C14H12O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h1-8,15-18H/b2-1+
InChIKey	PDHAOJSHSJQANO-OWOJBTEDSA-N
Boiling Point	523.8±30.0 °C at 760 mmHg
Melting Point	201°C
Flash Point	260.8±19.2 °C
Purity	98%
Density	1.468 g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Yellow powder
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	282
Exact Mass	244.07355886
Index Of Refraction	1.801
In Vitro	Cultures of the murine microglial cell line N9 and primary mixed glial cultures were used to test the drug effects of NO production upon expression of the inducible isoform of nitric oxide synthase (iNOS). Oxyresveratrol considerably diminished NO (nitrite) levels (IC50 of 45.31 µM) in murine microglial cells. Oxyresveratrol can inhibit DOPA oxidase activity, cyclooxygenase, and rat liver mitochondrial ATPase activity. Oxyresveratrol exhibits 63.3% inhibition at 100 µM and an IC50 value of 52.7 µM on the murine tyrosinase activity. Oxyresveratrol exhibits a dose-dependent inhibitory effect on L-tyrosine oxidation by the murine tyrosinase but does not inhibit the promoter activity of the enzyme gene. Oxyresveratrol exhibits significant inhibitory effects at 10 µM and higher concentrations on murine tyrosinase activity.
In Vivo	Oxyresveratrol (2-30 mg/kg; intraperitoneal injection; twice) treatment reduces the brain infarct volume in MCAO rats. Oxyresveratrol treatment diminishes cytochrome c release and decreased Caspase-3 activation, and reduces the number of apoptotic nuclei in ischemic brain in MCAO rats.
PSA	80.92000
Target	IC50: 1.2 µM (Mushroom tyrosinase); 28.9 µM (DPPH free radicals); 45.31 µM (NO) HSV-1, HSV-2, Varicella-zoster virus
Vapor Pressure	0.0±1.4 mmHg at 25°C
XLogP3-AA	2.8