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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Fiacitabine
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| Category | Herpes simplex Virus (HSV) |
| CAS | 69123-90-6 |
| Description | Fiacitabine is a selective inhibitior of DNA replication of herpes simplex virus(HSV). It was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloquanosine and slightly more toxic to normal cells. |
Product Information
| Synonyms | 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine; 5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinocytidine; FICA; DRG-0077; DRG 0077; DRG0077; FOAC; Fluoroiodoaracytidine; Fluorviodoaracytidine; 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one; 1-β-D-2'-Fluoroarabino-5-iodocytosine; 2'-Fluoro-5-iodo-1-β-D-arabinofuranosylcytosine; NSC 382097 |
| IUPAC Name | 4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one |
| Molecular Weight | 371.10 |
| Molecular Formula | C9H11FIN3O4 |
| Canonical SMILES | C1=C(C(=NC(=O)N1C2C(C(C(O2)CO)O)F)N)I |
| InChI | InChI=1S/C9H11FIN3O4/c10-5-6(16)4(2-15)18-8(5)14-1-3(11)7(12)13-9(14)17/h1,4-6,8,15-16H,2H2,(H2,12,13,17)/t4-,5+,6-,8-/m1/s1 |
| InChIKey | GIMSJJHKKXRFGV-BYPJNBLXSA-N |
| Boiling Point | 524.6±60.0 °C at 760 mmHg |
| Flash Point | 271.1±32.9 °C |
| Purity | ≥95% |
| Density | 2.44±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO |
| Appearance | White to off-white solid |
| Application | Antineoplastic Agents |
| Storage | Store at -20 °C |
| Complexity | 430 |
| Exact Mass | 370.97783 |
| Index Of Refraction | 1.791 |
| PSA | 110.60000 |
| Target | HSV |
| Vapor Pressure | 0.0±3.1 mmHg at 25°C |
| XLogP3-AA | -0.7 |
