Influenza Virus

CAS No.	Product Name	Inquiry
2250313-14-3	Influenza A virus-IN-1 Influenza A virus-IN-1, a dihydropyrrolidone derivative, is a potent inhibitor against wide subtypes of influenza A virus (IAV) with IC50s of 3.11-7.13 μM. It effectively inhibits the replication of IAV and up-regulates the expression of key antiviral cytokines IFN-β and antiviral protein MxA.
23094-71-5	Chebulagic acid Chebulagic acid is a polyphenol and tannin that has been found in T. chebula and has diverse biological activities. It is an inhibitor of COX-1, COX-2, and 5-lipoxygenase (5-LO; IC50s = 15, 0.92, and 2.1 μM, respectively) as well as α-glucosidase and 15-LO (IC50s = 0.05 and 24.9 μM, respectively). Chebulagic acid inhibit the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. And it can also inhibit the production of NO, prostaglandin E2 (PGE2), and reactive oxygen species (ROS), and nuclear translocation of NF-κB in RAW 264.7 macrophages in a concentration-dependent manner. Chebulagic acid also show a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease.
2364589-86-4	Cap-dependent-endonuclease-IN-3 Cap-dependent endonuclease-IN-3 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-3 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-3 has the potential for the research of influenza A and influenza B infection.
2379438-80-7	Compound Y-1 Compound Y-1 is a neuraminidase inhibitor with IC50 of 0.21 μM. Compound Y-1 exhibits activity against H1N1 influenza virus.
2390067-58-8	Influenza-A-virus-IN-4 Influenza A virus-IN-4 (compound 23b), an Oseltamivir derivative, is a potent inhibitor of neuraminidase. Influenza A virus-IN-4 exerts powerful inhibitions on Influenza Viruses.
2395007-75-5	RSV-IAV-IN-2 RSV/IAV-IN-2 (compound 14c) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-2 has lesser cytotoxicity than the clinical drug, Ribavirin. RSV/IAV-IN-2 has the potential for the research of RSV and/or IAV infections.
2395007-77-7	RSV-IAV-IN-1 RSV/IAV-IN-1 (compound 14e) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-1 has lesser cytotoxicity than the clinical drug, Ribavirin. RSV/IAV-IN-1 has the potential for the research of RSV and/or IAV infections.
2395007-81-3	RSV-IAV-IN-3 RSV/IAV-IN-3 (compound 14'i) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza A virus (IAV) with EC50 values of 2.92 µM and 1.90 µM,respectively. RSV/IAV-IN-3 has antiviral effect against H1N1 and H3N2 with EC50 values of 3.25 µM and 1.50 µM in MDCK cells, respectively. RSV/IAV-IN-3 significantly inhibits the activity of luciferase in a dose-dependent manner, with an EC50 of 3.89 µM. RSV/IAV-IN-3 inhibits IAV infectivity and RdRp activity. RSV/IAV-IN-3 inhibits IAV and RSV replication at the post-entry stage.
2407570-07-2	Antiviral-agent-20 Antiviral agent 20 is a selective inhibitor against Zika virus infection with an EC50 of 4.5 µM.
2411584-06-8	Influenza-virus-IN-2 Influenza virus-IN-2 (compound 19) is a potent influenza virus inhibitor with an EC50 of 2.58 μM and a CC50 of 150.85 μM. Influenza virus-IN-2 has concentration-dependent inhibitory activity against PAN endonuclease, with an EC50 of 489.39 nM. Influenza virus-IN-2 exhibits activity against influenza A virus.
2412451-16-0	Influenza-virus-IN-3 Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM.
2415788-71-3	Cap-dependent-endonuclease-IN-25 Cap-dependent endonuclease-IN-25 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-25 is a macrocyclic pyridotriazine derivative. Cap-dependent endonuclease-IN-25 has the potential for the research of viral infections caused by viruses belonging to the Orthomyxoviridae family.
2416258-53-0	Cap-dependent-endonuclease-IN-5 Cap-dependent endonuclease-IN-5 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-5 inhibits influenza virus well, and/or has lower cytotoxicity, better in vivo pharmacokinetic properties and in vivo pharmacodynamic properties.
24316-19-6	Cephalotaxine Antiviral and antitumor agent.
2454680-16-9	Cap-dependent-endonuclease-IN-8 Cap-dependent endonuclease-IN-8 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-8 inhibits replication of orthomyxoviruses (including influenza A, influenza B and influenza C).
2460686-97-7	Cap-dependent-endonuclease-IN-12 Cap-dependent endonuclease-IN-12 (EXP-35) is a potent Cap-dependent endonuclease inhibitor with low cytotoxicity. Cap-dependent endonuclease-IN-12 shows inhibitory activity against H1N1.
2464415-12-9	Influenza-A-virus-IN-5 Influenza A virus-IN-5 (Compound 16e) is a potent, orally active anti-influenza A virus (IAV) agent with an IC50 of 1.29 μM.
2464415-31-2	Influenza-A-virus-IN-6 Influenza A virus-IN-6 (compound 16j) is a potent and selective influenza A virus inhibitor with an IC50 of 3.88 µM and CC50 of 36.64 µM. Influenza A virus-IN-6 shows anti-IAV activity with low cytotoxicity.
2464415-40-3	Influenza-A-virus-IN-7 Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and 50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA
2473524-63-7	Neuraminidase-IN-5 Neuraminidase-IN-5 (Compound 5b) is a potent inhibitor of neuraminidase with an IC50 of 0.02 μM. Neuraminidase (NA) is a promising target for development of anti-influenza drugs. Neuraminidase-IN-5 is a dihydrofurocoumarin derivative compound.

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