Influenza Virus

CAS No.	Product Name	Inquiry
33830-10-3	1-Adamantanamine-[d15] 1-Adamantanamine-[d15] is a labelled form of Amantadine. Amantadine can be used as an antiviral and an antiparkinsonian drug. It is an NMDA receptor antagonist. Amantadine is also a useful building block in organic synthesis, allowing the insertion of an adamantyl group.
3411-37-8	Sophoranol Sophoranol is an alkaloid isolated from S. flavescens. Sophoranol shows potent antiviral activities against respiratory syncytial virus (RSV) with an IC50 of 10.4 μg/mL.
34580-13-7	Ketotifen Ketotifen is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators, used as self-medication for the temporary relief of itching of the eye due to allergic conjunctivitis (ophthalmic).
350818-67-6	Rimantadine-[d4] Hydrochloride Rimantadine-[d4] Hydrochloride is the labelled analogue of Rimantadine. Rimantadine is an antiviral drug used to treat influenzavirus A infection.
35891-70-4	Myriocin Myriocin is an unsaturated hydrocarbon and fatty acid derivative produced by Myriococcum albomyces NRRL 3858. It has antifungal activity.
371942-69-7	YM-201636 YM201636 is an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, can halt glucose entry by insulin in adipocytes. YM201636 almost completely inhibited basal and insulin-activated 2-deoxyglucose uptake at doses as low as 160 nM, with IC(50)=54+/-4 nM for the net insulin response. Insulin-induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those required for inhibition of insulin-induced phosphorylation of Akt/PKB. In addition to PIKfyve, YM201636 also completely inhibited insulin-dependent activation of class IA PI 3-kinase.
3731-59-7	Moroxydine Moroxydine is used as an antiviral drug against multiple DNA and RNA virus.
3738-70-3	Cephaeline hydrochloride Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.
381727-27-1	Loratadine-[d4] Loratadine-[d4] is the labelled analogue of Loratadine. Loratadine is a histamine H1 receptor antagonist, used to treat allergies.
38853-67-7	Tetrahydroepiberberine Tetrahydroepiberberine is an alkaloid showing antifungal and selective inhibition against the PI-3 virus activities.
40246-10-4	Glycitin Glycitin is an isoflavonoid recently found in flowers of Pueraria thunbergianaI. It can be modified into the metabolite glycitein which has anti-inflammatory properties. It promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It is effective in preventing bone loss and reversing the unfavorable changes of lipid metabolism. It may modulate differentiation of MSC to cause a lineage shift toward the osteoblast and away from the adipocytes, and could inhibit adipocytic transdifferen-tiation of osteoblasts. It could also be helpful in preventing the development of osteonecrosis.
422513-13-1	Hesperadin Hesperadin is an inhibitor of human Aurora B, which can prevent the phosphorylation of substrate with IC(50) of 40 nM. Growth of cultured bloodstream forms was also sensitive to Hesperadin (IC(50) of 50 nM). Hesperadin blocked nuclear division and cytokinesis but not other aspects of the cell cycle. Consequently, growth arrested cells accumulated multiple kinetoplasts, flagella and nucleoli, similar to the effects of RNAi-dependent knockdown of TbAUK1 in cultured bloodstream forms cells. Molecular models predicted high-affinity binding of Hesperadin to both conserved and novel sites in TbAUK1. Collectively, these data demonstrate that cell cycle progression is essential for infections with T. brucei and that parasite Aurora kinases can be targeted with small-molecule inhibitors.
433238-84-7	PP7 PP7 is a potent inhibitor of PB1-PB2 interaction with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity with an IC50 of 9.5 μM. It has antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50 = 1.4 μM), A(H7N9) and A(H9N2) subtypes.
4431-00-9	Aurintricarboxylic acid Aurintricarboxylic acid acts as a histological dye and an insulin-like growth factor receptor 1 antagonist.
443639-96-1	S119-8 S119-8, a broad-spectrum inhibitor of influenza A and B viruses, exhibits activity against a variety of influenza B viruses and oseltamivir resistant influenza A viruses, but does not inhibit non-influenza viruses, vesicular stomatitis viruses (VSV).
466-75-1	Haemanthamine Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with anticancer, pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities. It targets ribosomal that inhibits protein biosynthesis during the translational elongation phase.
475-81-0	BOLDINE DIMETHYL ETHER Glaucine isolated from the tubers of Corydalis yanhusuo.
476-32-4	Chelidonine Chelidonine, coming from the herbs of Chelidonium majus L, exhibits anti‑migratory and anti‑invasive effects in MDA‑MB‑231 cells, by suppressing COL‑I‑induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent down‑regulation of IPP downstream signaling molecules, such as Akt and ERK1/2. These results suggest that Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells. Its efficacy needs to be confirmed in animal models.
483-17-0	Cephaeline Cephaeline is an alkaloid, which is found in Cephaelis ipecacuanha and other plant species. It can reduce Zika virus (ZIKV) NS1 protein expression in HEK293 cells with IC50 of 26.4 nM and viral titer in ZIKV-infected SNB-19 cells with IC50 of 3.11 nM. Cephaeline can also induce vomiting by stimulating the stomach lining and is found in commercial products such as syrup of ipecac.
485-71-2	Cinchonidine Cinchonidine is an alkaloid found in Cinchona officinalis. It is used in asymmetric synthesis in organic chemistry. It is a stereoisomer and pseudo-enantiomer of cinchonine. Cinchonidine is a weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively.

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