Influenza Virus

CAS No.	Product Name	Inquiry
3731-59-7	Moroxydine Moroxydine is used as an antiviral drug against multiple DNA and RNA virus.
3738-70-3	Cephaeline hydrochloride Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.
381727-27-1	Loratadine-[d4] Loratadine-[d4] is the labelled analogue of Loratadine. Loratadine is a histamine H1 receptor antagonist, used to treat allergies.
38853-67-7	Tetrahydroepiberberine Tetrahydroepiberberine is an alkaloid showing antifungal and selective inhibition against the PI-3 virus activities.
40246-10-4	Glycitin Glycitin is an isoflavonoid recently found in flowers of Pueraria thunbergianaI. It can be modified into the metabolite glycitein which has anti-inflammatory properties. It promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It is effective in preventing bone loss and reversing the unfavorable changes of lipid metabolism. It may modulate differentiation of MSC to cause a lineage shift toward the osteoblast and away from the adipocytes, and could inhibit adipocytic transdifferen-tiation of osteoblasts. It could also be helpful in preventing the development of osteonecrosis.
405157-84-8	Drechslerine A Drechslerine A is a metabolite of the algicolous fungus Drechslera dematioidea.
405229-61-0	Nepasaikosaponin K Nepasaikosaponin K is a triterpene compound isolated from the dried roots of the umbelliferaceae plant Bupleurum chinense DC or Bupleurum scorzoner-ifolium Willd. It has anti-tumor (EAC), anti-hepatotoxic (rats, hepatocellular toxin caused by CCl4), anti-viral (influenza virus A2 in vitro, 50 μg/mL, inhibition rate 69%), anti-hyperlipidemia and anti-endotoxin effects. It has immunomodulatory function, as well as the effect of anti-platelet active factor, anti-allergy effect and anti-cell adhesion.
41653-73-0	Koaburaside Koaburaside is a natural phenol found in the herbs of Croton cascarilloides, it can suppress histamine release from mast cells. Koaburaside may have anti-allergic inflammatory activity. Koaburaside also has antioxidant activity with an IC50 value of 9.0μM.
422513-13-1	Hesperadin Hesperadin is an inhibitor of human Aurora B, which can prevent the phosphorylation of substrate with IC(50) of 40 nM. Growth of cultured bloodstream forms was also sensitive to Hesperadin (IC(50) of 50 nM). Hesperadin blocked nuclear division and cytokinesis but not other aspects of the cell cycle. Consequently, growth arrested cells accumulated multiple kinetoplasts, flagella and nucleoli, similar to the effects of RNAi-dependent knockdown of TbAUK1 in cultured bloodstream forms cells. Molecular models predicted high-affinity binding of Hesperadin to both conserved and novel sites in TbAUK1. Collectively, these data demonstrate that cell cycle progression is essential for infections with T. brucei and that parasite Aurora kinases can be targeted with small-molecule inhibitors.
4312-31-6	Chelidonine hydrochloride Chelidonine hydrochloride is a natural compound with profound antiviral and anti-inflammatory attributes, aiding in multifarious viral infections research.
433238-84-7	PP7 PP7 is a potent inhibitor of PB1-PB2 interaction with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity with an IC50 of 9.5 μM. It has antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50 = 1.4 μM), A(H7N9) and A(H9N2) subtypes.
4431-00-9	Aurintricarboxylic acid Aurintricarboxylic acid acts as a histological dye and an insulin-like growth factor receptor 1 antagonist.
443639-96-1	S119-8 S119-8, a broad-spectrum inhibitor of influenza A and B viruses, exhibits activity against a variety of influenza B viruses and oseltamivir resistant influenza A viruses, but does not inhibit non-influenza viruses, vesicular stomatitis viruses (VSV).
466-75-1	Haemanthamine Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with anticancer, pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities. It targets ribosomal that inhibits protein biosynthesis during the translational elongation phase.
475-81-0	Glaucine Glaucine is an aporphine alkaloid found in Platycapnos tenuiloba, Neolitsea parvigemma, and other organisms. Glaucine is an inhibitor of TNF-alpha and IL-6 production induced by Toll-like receptor (TLR) ligands.
476-32-4	Chelidonine Chelidonine, coming from the herbs of Chelidonium majus L, exhibits anti‑migratory and anti‑invasive effects in MDA‑MB‑231 cells, by suppressing COL‑I‑induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent down‑regulation of IPP downstream signaling molecules, such as Akt and ERK1/2. These results suggest that Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells. Its efficacy needs to be confirmed in animal models.
483-17-0	Cephaeline Cephaeline is an alkaloid, which is found in Cephaelis ipecacuanha and other plant species. It can reduce Zika virus (ZIKV) NS1 protein expression in HEK293 cells with IC50 of 26.4 nM and viral titer in ZIKV-infected SNB-19 cells with IC50 of 3.11 nM. Cephaeline can also induce vomiting by stimulating the stomach lining and is found in commercial products such as syrup of ipecac.
485-71-2	Cinchonidine Cinchonidine is an alkaloid found in Cinchona officinalis. It is used in asymmetric synthesis in organic chemistry. It is a stereoisomer and pseudo-enantiomer of cinchonine. Cinchonidine is a weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively.
487-11-6	Elemicin Elemicin is a alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by Metabolic activation. Elemicin is one of the main components in aromatic food and has antimicrobial, antioxidant, and antiviral activities. Elemicin possesses genotoxicity and carcinogenicity.
487-41-2	Phillyrin Phillyrin is a natural lignan compound that has anti-obesity effects. It can reduce tumor necrosis factor secreted by macrophages, which plays an important role in fat adipocyte dysfunction.

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