Glaucine

Category	Influenza Virus
CAS	475-81-0
Description	Glaucine is an aporphine alkaloid found in Platycapnos tenuiloba, Neolitsea parvigemma, and other organisms. Glaucine is an inhibitor of TNF-alpha and IL-6 production induced by Toll-like receptor (TLR) ligands.

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Synonyms	Boldine dimethyl ether; Bromcholitin; S-(+)-Glaucine; 1,2,9,10-Tetramethoxy-6a-alpha-aporphine
IUPAC Name	(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
Molecular Weight	355.43
Molecular Formula	C21H25NO4
Canonical SMILES	CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC
InChI	1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3/t15-/m0/s1
InChIKey	RUZIUYOSRDWYQF-HNNXBMFYSA-N
Boiling Point	487.0±45.0 °C at 760 mmHg
Melting Point	246-247°C
Flash Point	140.2±25.9 °C
Purity	98%
Density	1.166±0.06 g/cm3
Solubility	In Vitro: DMSO : 100 mg/mL(281.35 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (7.03 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (7.03 mM); Clear solution
Appearance	Powder
Application	Glaucine is a biologically active molecule that is used in the treatment of chronic cough.
Storage	4°C, protect from light * In solvent : -80°C, 6 months -20°C, 1 month (protect from light)
Complexity	489
Exact Mass	355.17835828
Index Of Refraction	1.576
PSA	40.16000
Target	Phosphodiesterase (PDE); Calcium Channel; Adrenergic Receptor; Dopamine
Vapor Pressure	0.0±1.2 mmHg at 25°C
XLogP3-AA	3.4