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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
S119-8
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| Category | Influenza Virus |
| CAS | 443639-96-1 |
| Description | S119-8, a broad-spectrum inhibitor of influenza A and B viruses, exhibits activity against a variety of influenza B viruses and oseltamivir resistant influenza A viruses, but does not inhibit non-influenza viruses, vesicular stomatitis viruses (VSV). |
Product Information
| Synonyms | 4-(tert-Butyl)-N-(4-(phenylamino)phenyl)benzamide; Benzamide, 4-(1,1-dimethylethyl)-N-[4-(phenylamino)phenyl]-; 4-(1,1-Dimethylethyl)-N-[4-(phenylamino)phenyl]benzamide; N-(4-Anilinophenyl)-4-(2-methyl-2-propanyl)benzamide |
| IUPAC Name | N-(4-anilinophenyl)-4-tert-butylbenzamide |
| Molecular Weight | 344.45 |
| Molecular Formula | C23H24N2O |
| Canonical SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)NC3=CC=CC=C3 |
| InChI | InChI=1S/C23H24N2O/c1-23(2,3)18-11-9-17(10-12-18)22(26)25-21-15-13-20(14-16-21)24-19-7-5-4-6-8-19/h4-16,24H,1-3H3,(H,25,26) |
| InChIKey | NEPKMQDGCTXOPG-UHFFFAOYSA-N |
| Boiling Point | 447.3±38.0°C at 760 mmHg |
| Flash Point | 128.3±26.9 °C |
| Purity | ≥95% |
| Density | 1.1±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | White to Beige Powder |
| Storage | Store at 2-8°C |
| Complexity | 434 |
| Exact Mass | 344.188863393 |
| Index Of Refraction | 1.641 |
| In Vitro | S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improved calculated physical properties, while maintaining significant potency (IC50=1.43 μM) at non-toxic (CC50=66.10 μM) concentrations, albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV). S119-8 has increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. S119-8 inhibits Influenza Viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC50 of 6.05 μM. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC50 of 8.42 μM. |
| Target | Influenza Virus |
| Vapor Pressure | 0.0±1.1 mmHg at 25°C |
| XLogP3-AA | 5.8 |
