CYP2C19-IN-1

Category	Influenza Virus
CAS	3010895-53-8
Description	CYP2C19-IN-1 is a selective inhibitor of the CYP2C19 enzyme, which is crucial for the metabolism of various medications, including antiplatelet drugs and proton pump inhibitors. CYP2C19-IN-1 inhibits RNA-dependent RNA polymerase (RdRP) with a Ki of 6.16 µM. By inhibiting CYP2C19, this compound can alter the metabolism and effectiveness of these drugs, potentially enhancing or prolonging their therapeutic effects and reducing the risk of adverse drug interactions. This inhibition is particularly relevant for optimizing treatments in patients who require precise drug dosing or are affected by variable drug metabolism.

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Synonyms	2-Naphthalenemethanesulfonic acid, 6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-; (6-(3-(tert-Butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonic acid
IUPAC Name	[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonic acid
Molecular Weight	494.56
Molecular Formula	C26H26N2O6S
Canonical SMILES	CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)CS(=O)(=O)O)N4C=CC(=O)NC4=O
InChI	InChI=1S/C26H26N2O6S/c1-26(2,3)22-14-20(28-10-9-23(29)27-25(28)30)13-21(24(22)34-4)19-8-7-17-11-16(15-35(31,32)33)5-6-18(17)12-19/h5-14H,15H2,1-4H3,(H,27,29,30)(H,31,32,33)
InChIKey	CJIIKXVGUILPKR-UHFFFAOYSA-N
Density	1.340±0.06 g/cm3
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.