SARS-CoV

CAS No.	Product Name	Inquiry
184904-82-3	SARS-CoV-2-IN-18 SARS-CoV-2-IN-18 (Compound 26) is a potent SARS-CoV-2 3C-like protease inhibitor with an IC50 of 45 nM. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals.
1854126-41-2	Chloroquine-[d5] Chloroquine-[d5], is the labelled analogue of Chloroquine. Chloroquine is an antimalarial agent.
1854126-42-3	Chloroquine-[d5] Diphosphate Chloroquine-[d5] Diphosphate, is the labelled analogue of Chloroquine Diphosphate. Chloroquine phosphate is an antimalarial drug and weak intercalating agent. It inhibits TLR signalling in plasmacytoid dendritic cells (pDCs). It has been used in emergency of COVID-19.
1854126-45-6	Hydroxychloroquine-d4-sulfate Hydroxychloroquine-d4 sulfate (HCQ-d4 sulfate) is the deuterium labeled Hydroxychloroquine sulfate. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling.
1862212-48-3	TH 1217 TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor with IC50 value of 47 nM.
187034-31-7	TAPI-2 TAPI-2 is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE; ADAM17), other ADAMs and matrix metalloproteinases (MMPs). It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-α, β amyloid precursor protein, L-selectin, and IL-6 receptor α subunit.
1910-68-5	N-METHYLISATIN-3-THIOSEMICARBAZONE Methisazone (Marboran) is an antiviral agent that works by inhibiting mRNA and protein synthesis. Methisazone is also a SARS-CoV-2 (COVID-19) inhibitor. Methisazone is mainly used in pox viruses.
1911578-74-9	Remdesivir nucleoside monophosphate Remdesivir is a nucleoside analogue with effective antiviral activity against SARS-CoV and MERS-CoV. Remdesivir nucleoside monophosphate is a metabolite of Remdesivir, which has a role as an anticoronaviral agent, is an antiviral drug and a drug metabolite.
201677-61-4	Sivelestat sodium tetrahydrate Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki = 0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase.
2050041-12-6	Ledipasvir-[d6] Ledipasvir-[d6] is the labelled form of Ledipasvir, which is intended for use as an internal standard for the quantification of ledipasvir by GC-or LC-MS.
2098191-53-6	Zotatifin Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM). Zotatifin induces cell Apoptosis.
2098191-54-7	rel-Zotatifin Zotatifin is an eIF4A inhibitor. rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin.
2140-72-9	2'-O-Methylcytidine Cytidine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
2144491-78-9	(Rac)-X77 (Rac)-X77 also known as MUN91789, is a potent inhibitor of SARS-CoV-2 main protease.
2172676-02-5	Velpatasvir-[d7] Velpatasvir-[d7] is the labelled analogue of Velpatasvir, which is a selective Hepatitis C virus NS 5 protein inhibitor.
222631-44-9	BCX 4430 hydrochloride BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells. Interfering with the replication process is a well-established antiviral strategy that has been successfully exploited in developing such life-saving drugs as the nucleoside inhibitors of HIV and acyclovir for herpes simplex complex. BCX4430 may be suitable for administration by intravenous (IV), intramuscular (IM), and oral (PO) routes.
2244991-17-9	SARS-CoV-2-IN-19 SARS-CoV-2-IN-19 (Compound 6g) is a potent inhibitor of SARS-CoV-2 with an EC50 of 8.8 μM. SARS-CoV-2-IN-19 shows potent activity against SARS-CoV-2 helicase (nsp13), a highly conserved enzyme, highlighting a potentiality against emerging HCoVs outbreaks. SARS-CoV-2-IN-19 has the potential for the research of infection diseases.
2245195-67-7	HeE1-2Tyr HeE1-2Tyr and related derivatives were originally discovered as inhibitors of the RdRp of flaviviruses, which significantly inhibit SARS-CoV-2 RdRp.
2245697-92-9	MERS-CoV-IN-1 MERS-CoV-IN-1 exhibits excellent inhibitory activity against coronavirus, which has the potential for COVID-19 research.
229975-97-7	Atazanavir Sulfate Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM. It is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus.

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