SARS-CoV

CAS No.	Product Name	Inquiry
611-75-6	Bromhexine hydrochloride Bromhexine is a mucolytic (expectorant) agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties.
61422-45-5	Carmofur Carmofur or HCFU is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil.
614-60-8	trans-2-Hydroxycinnamic acid 2-Hydroxycinnamic acid is found in the herbs of Angraecum fragrans, it has photooxidant activity.
622794-09-6	SARS-CoV-2 3CLpro-IN-13
64706-54-3	bepridil Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells.
65666-07-1	Silymarin Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant. It exhibits in vitro antiviral, antibacterial, antifungal activities and cytotoxicity.
665026-57-3	Bananin Bananin is an effective adamantane-related molecule with antiviral activity, which has the potential for SARS-CoV research.
67526-95-8	Thapsigargin Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrug formulations. In cells, sarco/endoplasmic calcium ATPases (SERCAs) transport free calcium into the sarcoplasmic and endoplasmic reticula, lowering intracellular calcium levels to stop signaling through this cation. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM). Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. In vivo, thapsigargin and related sesquiterpene lactones have anti-inflammatory and anti-cancer effects.
69235-50-3	Acriflavine-hydrochloride Acriflavine hydrochloride is a potent HIF-1 inhibitor, with antitumor activity. It also has antimicrobial and antiviral activities. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2.
69431-87-4	Setomimycin It is produced by the strain of Str. pseudovenezuelae AM-2947. It has anti-gram-positive bacteria and mycobacteria effects, and has the effect of inhibiting sarcoma-180.
70209-81-3	Ivermectin B1b Ivermectin B1b is a minor component of Ivermectin, a semi-synthetic derivative of Abamectin. Ivermectin is a medication that is effective against many types of parasites.
71079-08-8	FOY 251 free base
714923-33-8	FWM-3 FWM-3 is a potent SARS-CoV-2 NSP13 helicase inhibitor.
71827-03-7	Ivermectin B1a It is the major component (>80%) of the commercial anthelmintic, ivermectin. It exerts its anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. It is also a potent insecticide.
71835-79-5	Antioxidant agent-9
753015-44-0	Simpinicline Simpinicline is a nicotinic acetylcholine receptor (nAChR) agonist. nAChRs are thought to play a role in a variety of neurocognitive processes and have been a pharmacologic target for disorders with cognitive impairment, including schizophrenia and Alzheimer's disease.
76684-89-4	E 64c E-64c is a cysteine protease inhibitor used for detecting autophagy in plants.
76822-21-4	Danshensu Danshensu is an active component of Salvia miltiorrhiza that shows wide cardiovascular benefit. It suppresses the formation of reactive oxygen species and inhibits platelet adhesion and aggregation. It also protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. It increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. It may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation. It significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size in vitro. It also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis. It significantly lowered tHcy in rats with elevated tHcy. Danshensu is a natural compound, which can also be used in cosmetics material.
76996-28-6	garcinone B
778270-11-4	GNF-2 GNF-2 is a Bcr-Abl inhibitor that binds to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. Thus, it can selectively inhibit Bcr-Abl phosphorylation (IC50 = 267 nM) without affecting native c-Abl or a panel of 63 additional kinases.

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