SARS-CoV

CAS No.	Product Name	Inquiry
1425038-27-2	MK-5172 sodium salt In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a. In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr. When dosed p.o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 uM.hr. The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p.o. 5 mg/kg dose. At 24 hr, the liver concentration of MK-5172 was 0.2 uM, which was over 25-fold higher than the IC50 in the replicon assay with 50% NHS. When dosed to dogs, MK-5172 showed low clearance of 5 ml/min/kg and a 3 hr half-life after i.v. 2 mg/kg dosing and had good plasma exposure (AUC=0.4 uM.hr) after a p.o. 1 mg/kg dose.
1444827-29-5	Aviptadil-acetate Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. It induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure.
1453052-57-7	SARS-CoV-2-IN-9 SARS-CoV-2 Nucleotide Analog RNA Polymerase Inhibitor. SARS-CoV-2-IN-9 is an inhibitor binding to subsites S1 and S2 in SARS-CoV-2 main protease.
1454555-29-3	LP-935509 LP-935509 is a brain penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50 value 3.3 nM and 14 nM and 320 nM for the closely related BIKE and GAK enzymes, repsectively). LP-935509 exhibits antinociceptive property in multiple rat models of neuropathic pain, but not acute pain. The antinociception of AAK1 inhibitor can be blocked by α2 adrenergic antagonists.
145-63-1	Suramin Suramin, also called as Germanin, has been demonstrated to inhibit a large variety of enzymes including urease, hexokinase, succinic dehydrogenase, p-glucuronidase, acid phosphatase, lysozyme, thrombin, plasma kallikrein, (Na'-K')-activated ATPase, plasmi
1456607-71-8	Paritaprevir-dihydrate Paritaprevir (ABT-450) dihydrate is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir dihydrate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.31 μM. Paritaprevir dihydrate is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir dihydrate can be enhanced by Ritonavir (a CYP450 inhibitor).
1471484-62-4	YH-53 YH-53 strongly blocks the SARS-CoV-2 replication, which is the potential for COVID-19 research.
149759-26-2	Pinokalant Pinokalant is a broad-spectrum and non-selectivecation channel inhibitor. Pinokalant significantly reduces cortical infarct volume. Pinokalant o improves the Metabolic and electrophysiologic status of the ischemic penumbra. Pinokalant reduces lesion size on magnetic resonance images in the acute phase following middle cerebral artery occlusion in rats. Pinokalant has the potential for the research of stroke. Pinokalant also shows anti-SARS-CoV-2 activity.
150374-95-1	Sivelestat sodium Sivelestat sodium(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.
1523404-29-6	Vps34-IN-2 Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively.
154-42-7	Thioguanine Thioguanine incorporation alters the DNA cleavage induced by topoisomerase II in the presence and absence of etoposide
1580-42-3	SARS-CoV-2-IN-15 SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally.
161511-45-1	SDZ 224-015 SDZ 224-015 is an inhibitor of the interleukin-1 beta converting enzyme.
1621884-18-1	AT-9010 tetrasodium AT-9010 tetrasodium can inhibit SARS-CoV-2 replication.
1646818-35-0	Ribavirin-[13C5] Ribavirin-[13C5] is the labelled analogue of Ribavirin. Ribavirin is an anti-viral medication used to treat RSV infection, hepatitis C, and viral hemorrhagic fever.
172906-90-0	PB-28 PB28 is a cyclohexylpiperazine derivative and a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. PB28 is also a σ1 antagonist with a Ki of 0.38 nM. PB28 is less affinity for other receptors. PB28 inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. PB28 can modulate SARS-CoV-2-human protein-protein interaction. PB28 induces Caspase-independent Apoptosis and has antitumor activity.
172907-03-8	PB 28 dihydrochloride PB 28 dihydrochloride is a high affinity σ2 receptor agonist. It displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
174484-41-4	Tipranavir Tipranavir, a nonpeptidic HIV protease inhibitor (NPPI), inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-PI-resistant HIV-1 isolates.
17795-26-5	S-Allyl-L-cysteine sulfoxide Alliin is a cysteine sulfoxide constituent of garlic that is converted by alliinase to allicin, which imparts its pungent aroma and flavor.
1789738-04-0	AMY-101 TFA C3 Complement Inhibitor AMY-101 is a compstatin-based inhibitor of human complement component C3. AMY-101 TFA exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.

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