SARS-CoV

all Chemical (1) Inhibitors (588) Modulators (2)

CAS No.	Product Name	Inquiry
2492423-29-5	EIDD-2801 EIDD-2801, derived from N4-hydroxycytidine, is an oral bioavailable broad-spectrum antiviral compound that is effective against SARS-CoV2 infection.
1191237-69-0	GS-441524 GS-441524 is an analog nucleotide inhibitor against feline infectious peritonitis virus (FIPV). EC50 is 0.78 uM. GS-441524 is also a metabolite and intermediate of Remdesivir.
155213-67-5	Ritonavir Ritonavir is an HIV protease inhibitor. It is often used in a low dose with another protease inhibitor lopinavir. Ritonavir was approved for COVID-19 treatment in combination with Nirmatrelvir.
118-42-3	Hydroxychloroquine Hydroxychloroquine is a synthetic antimalarial agent and it can inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine efficiently inhibits SARS-CoV-2 infection in vitro.
679809-58-6	Enoxaparin sodium Enoxaparin sodium is an anticoagulant medication used for the prevention of blood clots such as deep vein thrombosis (DVT), and also for the treatment of blood vessel complications in patients with angina and heart attack.
2628280-40-8	PF-07321332 PF-07321332 is an orally available SARS-CoV 3C-like protease (3CLPRO) inhibitor. 3C-like protease (3CLPRO) is the main protease found in coronaviruses, which cleaves the coronavirus polyprotein at eleven conserved sites. PF-07321332 has demonstrated oral activity in a mouse-adapted SARS-CoV-2 model and has achieved oral plasma concentrations exceeding the in vitro antiviral cell potency in a phase I clinical trial in healthy human participants.
3258-02-4	EIDD-1931 EIDD-1931 is a ribonucleoside analog that exhibits potential antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV. EIDD-1931 induces mutations in RNA virions, inhibiting SARS-CoV-2 and other coronavirus in mice and human airway epithelial cells.
82956-11-4	Nafamostat mesilate Nafamostat Mesylate is a synthetic serine protease inhibitor and an anticoagulant. It is a fast-acting proteolytic inhibitor and used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin.
137219-37-5	Plitidepsin Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin shows potent anticancer activity against a large variety of cultured human cancer cells, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.
1809249-37-3	Remdesivir Remdesivir, an analog nucleotide inhibitor, with effectively antiviral activity in vitro against various virus, including Ebola virus, Marburg virus, HCoV-NL63, HCoV-OC43, HCoV-229E, Mouse hepatitis virus (MHV), SARS-CoV, MERS-CoV and related bat coronavirus, HKU5, and PDCoV (porcine delta-coronavirus). Remdesivir is also reported to have potential antiviral activity against a 2019 novel coronavirus (called 2019-nCoV, nCoV2019 or COVID-19).
2036272-55-4	Lipid ALC-0315 ALC-0315 can be used to form lipid nanoparticle (LNP, non-viral gene delivery system).

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