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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
UNC2881
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| Category | Vesicular stomatitis virus (VSV) |
| CAS | 1493764-08-1 |
| Description | UNC2881 is a potent Mer kinase inhibitor. UNC2281 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis. |
Product Information
| Synonyms | UNC2881;1493764-08-1;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide;UNC 2881;CHEMBL3093756;2-(butylamino)-4-[(4-hydroxycyclohexyl)amino]-N-[(4-imidazol-1-ylphenyl)methyl]pyrimidine-5-carboxamide;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide;SCHEMBL16435501;SCHEMBL17167888;SCHEMBL25422930;HMS3653M12;HMS3747I07;BCP12436;EX-A2176;UNC-2881;UNC2881?;BDBM50444241;s7325;AKOS024464756;AKOS026750571;CCG-269383;CS-3255;NCGC00390386-01;NCGC00485937-01;AC-31424;AS-55931;BU167099;DA-44177;HY-15798;PD052365;UNC2881, >=98% (HPLC);SW220192-1;C72843;2-(butylamino)-4-[(4-hydroxycyclohexyl)amino]-N-{[4-(imidazol-1-yl)phenyl]methyl}pyrimidine-5-carboxamide;2-(butylamino)-N-{[4-(imidazol-1-yl)phenyl]methyl}-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide;N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1s,4s)-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide; |
| IUPAC Name | 2-(butylamino)-4-[(4-hydroxycyclohexyl)amino]-N-[(4-imidazol-1-ylphenyl)methyl]pyrimidine-5-carboxamide |
| Molecular Weight | 463.58 |
| Molecular Formula | C25H33N7O2 |
| Canonical SMILES | CCCCNC1=NC(N[C@H]2CC[C@H](O)CC2)=C(C(NCC3=CC=C(N4C=NC=C4)C=C3)=O)C=N1 |
| InChI | InChI=1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33H,2-3,6-7,10-12,15H2,1H3,(H,28,34)(H2,27,29,30,31) |
| InChIKey | NPVXOWLPOFYACO-UHFFFAOYSA-N |
| Purity | 98% |
| Density | 1.31±0.1 g/cm3(Predicted) |
| Appearance | Solid |
